EVIDENCE THAT PYRIMIDINE DIMERS IN DNA CAN GIVE RISE TO TUMORS
EVIDENCE THAT PYRIMIDINE DIMERS IN DNA CAN GIVE RISE TO TUMORS
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DOI：
10.1073/pnas.74.12.5574
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发表时间：
1977-01-01
影响因子：
11.1
通讯作者：
WOODHEAD, AD
中科院分区：
文献类型：
--
作者：
HART, RW;SETLOW, RB;WOODHEAD, AD
The Amazon molly, Poecilia formosa, is a small fish that grows in clones. Cells from 1 animal may be transplanted to another without danger of rejection. Cells from thyroid and adjacent tissue were irradiated with UV light in vitro and injected into the abdominal cavity of isogeneic recipients. At appropriate UV doses and numbers of cells injected, all recipients showed exuberant thyroid proliferation. Arguments and data indicating that the proliferation is a tumor, not a goitrogenic response were given. If the UV irradiation is followed, but not preceded, by photoreactivating illumination, the yield of thyroid growths is decreased. Because other investigations showed that photoreactivation monomerizes UV-induced cyclobutylpyrimidine dimers in DNA and does not affect other photoproducts, pyrimidine dimers in DNA can give rise to tumors.
