Visual Recognition Memory: A Double Anatomo-Functional Dissociation
Visual Recognition Memory: A Double Anatomo-Functional Dissociation
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DOI：
10.1002/hipo.20848
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发表时间：
2011-09-01
期刊：
影响因子：
3.5
通讯作者：
Puel, Michele
中科院分区：
文献类型：
--
作者：
Barbeau, Emmanuel J.;Pariente, Jeremie;Puel, Michele
关于前海马下结构和海马在识别记忆中的各自作用有一个持续的争论。在这里，我们报告了双重解剖功能分离观察两个脑损伤患者，FRG和JMG。他们都遭受了左MTL结构的完全破坏。然而，在右半球，FRG持续对海马进行广泛的损伤，保留了前海马下结构，而JMG遭受了相反的损伤模式，即，海马体前部下结构大面积受损但海马体得以保留。FRG是严重的健忘症和失败的所有回忆任务涉及视觉材料，但表现出正常的性能在一个大电池的视觉识别记忆任务。JMG没有失忆，表现出相反的表现模式。这些结果有力地支持了右前海马下结构是人类视觉识别记忆的关键中继的观点。(C)2010 Wiley-Liss，Inc.
There is an ongoing debate regarding the respective role of anterior subhippocampal structures and the hippocampus in recognition memory. Here, we report a double anatomo-functional dissociation observed in two brain-damaged patients, FRG and JMG. They both suffered from complete destruction of left MTL structures. In the right hemisphere however, FRG sustained extensive lesions to the hippocampus sparing anterior subhippocampal structures, while JMG suffered from the reversed pattern of lesion, i.e., extensive damage to anterior subhippocampal structures but preserved hippocampus. FRG was severely amnesic and failed all recall tasks involving visual material, but exhibited normal performance at a large battery of visual recognition memory tasks. JMG was not amnesic and showed the opposite pattern of performance. These results strongly support the view that right anterior subhippocampal structures are a critical relay for visual recognition memory in the human. (C) 2010 Wiley-Liss, Inc.