Chlorogentisylquinone, a new neutral sphingomyelinase inhibitor, produced by a marine fungus
Chlorogentisylquinone, a new neutral sphingomyelinase inhibitor, produced by a marine fungus
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DOI：
10.7164/antibiotics.54.882
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发表时间：
2001-11-01
影响因子：
3.3
通讯作者：
Omura, S
中科院分区：
文献类型：
--
作者：
Uchida, R;Tomoda, H;Omura, S
Chlorogentisylquinone, a new inhibitor of neutral sphingomyelinase activity, was purified from the culture broth of a fungal strain FOM-8108 isolated from a marine environment by solvent extraction, silica gel chromatography and Sephadex LH-20 chromatography. Its chemical structure was elucidated by spectroscopic studies including H-1, C-13, DEPT, HMQC and HMBC NMR experiments. Chlorogentisylquinone inhibited neutral sphingomyelinase activity of rat brain membranes with an IC50 value of 1.2 mum.
