Corticotropin-releasing factor induces social preferences in male prairie voles
Corticotropin-releasing factor induces social preferences in male prairie voles
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DOI：
10.1016/s0306-4530(01)00073-7
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发表时间：
2002-08-01
影响因子：
3.7
通讯作者：
Carter, CS
中科院分区：
文献类型：
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作者：
DeVries, AC;Guptaa, T;Carter, CS
暴露于压力源有助于一夫一妻制雄性草原田鼠（田鼠）社会偏好的形成。在本研究中，我们测试了这样的假设：促肾上腺皮质激素释放因子（CRF）（一种在应激过程中释放的神经肽）治疗能够诱导雄性草原田鼠的社交偏好。评估了五剂 CRF（0.01、0.1、1.0、10 和 100 ng；静脉注射）对社会偏好的影响。外源性 CRF 并没有改变实验动物和伴侣在最初同居期间发生的社会接触量。然而，在同居 3 小时后进行测试时，接受 0.1 或 1.0 ng CRF 治疗的动物与伴侣身体接触的时间明显多于陌生人。相比之下，3小时的同居不足以诱导用人工脑脊液载体或其他剂量的CRF预处理的动物的社会偏好。此外，联合使用 CRF 受体拮抗剂可防止 CRF 诱导的社会偏好的形成。这些数据为下丘脑-垂体-肾上腺轴在草原田鼠社会联系中的作用提供了支持。 (C) 2002 年，爱思唯尔科学有限公司出版。
Exposure to stressors facilitates the formation of social preferences in monogamous male prairie voles (Microtus ochrogaster). In the present study, the hypothesis was tested that treatment with corticotropin-releasing factor (CRF), a neuropeptide released during stress, is capable of inducing social preferences in male prairie voles. The effects of five doses of CRF (0.01, 0.1, 1.0, 10 and 100 ng; i.c.v.) on social preference were assessed. Exogenous CRF did not alter the amount of social contact that occurred between the experimental animal and partner during the initial cohabitation period. However, when tested after 3 h of cohabitation, animals that had been treated with 0.1 or 1.0 ng CRF spent significantly more time in physical contact with the partner than a stranger. In contrast, 3 h of cohabitation was not sufficient to induce social preferences in animals pre-treated with an artificial CSF vehicle or other doses of CRF. Furthermore, co-administration of a CRF receptor antagonist prevented the formation of CRF-induced social preferences. These data provide support for a role of the hypothalamic-pituitary-adrenal axis in social bonding in prairie voles. (C) 2002 Published by Elsevier Science Ltd.