The effect of amantadine on mouse hepatitis virus replication.
The effect of amantadine on mouse hepatitis virus replication.
复制标题
金刚烷胺对小鼠肝炎病毒复制的影响。
DOI：
10.1007/978-1-4615-2996-5_19
复制
发表时间：
1993
影响因子：
--
通讯作者：
Reneker,SJ
中科院分区：
文献类型：
--
作者：
Leibowitz,JL;Reneker,SJ
Amantadine has been known to be a potent inhibitor of influenza A virus infection for many years (1). Although amantadine’s antiviral effect on many other viruses is much less potent that observed for influenza A, it does have a fairly broad antiviral spectrum (2,3). The extreme sensitivity of influenza A virus to the drug has been shown by genetic and molecular biologic studies to reside with the M2 protein. Amantadine interacts with M2 and inhibits its ability to function as a pH-gated ion channel, and thus appears to interfere with a step in influenza virus uncoating and assembly (4–6). Amantadine exerts its more broad-spectrum antiviral effects by virtue of its lysomotropic properties. The drug accumulates in endocytic vesicles, raises their pH, and thus interferes with the ability of viruses requiring low pH to complete uncoating and penetration from entering the cytosol (2,3).
