Cancer-testis antigen expression in triple-negative breast cancer
Cancer-testis antigen expression in triple-negative breast cancer
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DOI：
10.1093/annonc/mdq325
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发表时间：
2011-01-01
影响因子：
50.5
通讯作者：
Goldhirsch, A.
中科院分区：
文献类型：
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作者：
Curigliano, G.;Viale, G.;Goldhirsch, A.
背景：睾丸癌（CT）抗原经常在人类生殖细胞中表达，而不在体细胞组织中表达，可能在不同类型的癌症中异常地重新表达。本研究的目的是探讨CT抗原在乳腺癌中的表达。患者和方法：选择100例浸润性乳腺癌，其中雌激素受体（ER）阳性/HER2阴性50例，三阴性（TN） 50例，采用免疫组化方法检测NY-ESO-1和MAGE-A的表达。结果：在TN乳腺癌中MAGE-A和NY-ESO-1的表达明显高于er阳性肿瘤（P = 0.04）。在13例（26%）TN肿瘤中检测到MAGE-A表达，而在5例（10%）er阳性肿瘤中检测到MAGE-A表达（P = 0.07）。NY-ESO-1在9例（18%）TN肿瘤样本中被证实表达，而在2例（4%）er阳性肿瘤中被证实表达。结论：MAGE-A和NY-ESO-1 CT抗原在相当比例的TN乳腺癌中表达。由于这组患者的治疗选择有限，基于CT抗原的疫苗可能被证明对患有这种表型的乳腺癌患者有用。
Background: Cancer-testis (CT) antigens, frequently expressed in human germline cells but not in somatic tissues, may become aberrantly reexpressed in different cancer types. The aim of this study was to investigate the expression of CT antigens in breast cancer.Patients and methods: A total of 100 selected invasive breast cancers, including 50 estrogen receptor (ER) positive/HER2 negative and 50 triple negative (TN), were examined for NY-ESO-1 and MAGE-A expression by immunohistochemistry.Results: A significantly higher expression of MAGE-A and NY-ESO-1 was detected in TN breast cancers compared with ER-positive tumors (P = 0.04). MAGE-A expression was detected in 13 (26%) TN cancers compared with 5 (10%) ER-positive tumors (P = 0.07). NY-ESO-1 expression was confirmed in nine (18%) TN tumor samples compared with two (4%) ER-positive tumors.Conclusions: MAGE-A and NY-ESO-1 CT antigens are expressed in a substantial proportion of TN breast cancers. Because of the limited therapeutic options for this group of patients, CT antigen-based vaccines might prove to be useful for patients with this phenotype of breast cancer.