Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER.
Development of SPECT imaging agents for the norepinephrine transporters: [123I]INER.
复制标题
开发去甲肾上腺素转运蛋白的 SPECT 显像剂：[123I]INER。
DOI：
10.1016/j.bmcl.2006.10.018
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发表时间：
2007
影响因子：
2.7
通讯作者：
Seibyl,JohnP
中科院分区：
文献类型：
--
作者：
Tamagnan,GillesD;Brenner,Eric;Alagille,David;Staley,JulieK;Haile,Colin;Koren,Andrei;Early,Michelle;Baldwin,RonaldM;Tarazi,FrankI;Baldessarini,RossJ;Jarkas,Nachwa;Goodman,MarkM;Seibyl,JohnP
A series of reboxetine analogs was synthesized and evaluated for in vitro binding as racemic mixtures. The best candidate (INER) was synthesized as the optically pure (S,S) enantiomer, labeled with iodine-123 and its in vivo binding determined by SPECT imaging in baboons. The in vivo specificity, selectivity, and kinetics of [123I]INER make it a promising agent for imaging NET in vivo by noninvasive SPECT imaging.
