Association between Helicobacter pylori infection and triglyceride levels: a nested cross-sectional study.
Association between Helicobacter pylori infection and triglyceride levels: a nested cross-sectional study.
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DOI：
10.3389/fendo.2023.1220347
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发表时间：
2023
影响因子：
5.2
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中科院分区：
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目前，关于脂质谱与幽门螺杆菌（H. pylori）感染是有限的和矛盾的。也有一个缺乏的研究，探讨了性别特异性差异的可能性，在关联H。幽门感染和甘油三酯水平。我们利用1999-2000年在美国进行的国家健康与营养检查调查（NHANES）的数据进行了一项涉及1，146名参与者的横断面研究。Logistic回归模型用于评估H。幽门螺杆菌血清阳性和甘油三酯水平。进行了按性别分层的亚组分析，以探讨这种关联的性别特异性差异。血清甘油三酯水平显著高于H。pylori血清学阳性的参与者比H.幽门血清阴性参与者。Logistic回归分析显示，H. pylori血清阳性率与甘油三酯水平相关（OR=1.231，95% CI为1.016-1.491，P=0.033）。在亚组分析中，血清甘油三酯和H。pylori血清阳性率在女性中有显著性差异（OR=1.732; 95%CI，1.113-2.696; P=0.015），但在男性中无显著性差异（OR=1.091; 95%CI，0.698-1.705; P=0.704）。高甘油三酯水平与H。幽门螺杆菌感染是女性特有的。
Currently, the available evidence regarding the relationship between the lipid profile and Helicobacter pylori (H. pylori) infection is limited and conflicting. There is also a dearth of studies that have explored the possibility of sex-specific differences in the association between H. pylori infection and triglyceride levels. We conducted a cross-sectional study involving 1,146 participants utilizing data from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 conducted in the United States. A logistic regression model was employed to evaluate the association between H. pylori seropositivity and triglyceride levels. Subgroup analyses stratified by sex were conducted to explore sex-specific differences in this association. Serum triglyceride levels were significantly higher in H. pylori-seropositive participants than in H. pylori-seronegative participants. In the logistic regression analysis, there was a positive correlation between H. pylori seropositivity and triglyceride levels (OR=1.231; 95% CI, 1.016-1.491; P=0.033). In the subgroup analysis, the adjusted association between serum triglycerides and H. pylori seropositivity was significant in females (OR=1.732; 95% CI, 1.113-2.696; P=0.015) but not in males (OR=1.091; 95% CI, 0.698-1.705; P=0.704). The association between high triglyceride levels and H. pylori infection is specific to the female population.