miR-223-3p promotes autoreactive Th17 cell responses in experimental autoimmune uveitis (EAU) by inhibiting transcription factor FOXO3 expression
miR-223-3p promotes autoreactive Th17 cell responses in experimental autoimmune uveitis (EAU) by inhibiting transcription factor FOXO3 expression
复制标题
miR-223-3p 通过抑制转录因子 FOXO3 表达促进实验性自身免疫性葡萄膜炎 (EAU) 中自身反应性 Th17 细胞反应
DOI：
10.1096/fj.201901446r
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发表时间：
2019-12-01
期刊：
影响因子：
4.8
通讯作者：
Nian, Hong
中科院分区：
文献类型：
--
作者：
Wei, Yankai;Chen, Sisi;Nian, Hong
Pathogenic T helper (Th)17 cells are key mediators of autoimmune diseases such as uveitis and its animal model, experimental autoimmune uveitis (EAU). However, the contribution of microRNAs (miRs) to the intrinsic control of pathogenic Th17 cells in EAU remains largely unknown. Here, we have reported that miR‐223‐3p was significantly up‐regulated in interphotoreceptor retinoid‐binding protein‐specific Th17 cells, and its expression was enhanced by IL‐23‐signal transducer and activator of transcription 3 signaling. Knockdown of miR‐223‐3p decreased the pathogenicity of Th17 cells in a T‐cell transfer model of EAU. Mechanistic studies showed that miR‐223‐3p directly repressed the expression of forkhead box O3 (FOXO3), and FOXO3 negatively regulated pathogenic Th17 cell responses partially via suppression of IL‐23 receptor expression. Thus, our results reveal an important role for miR‐223‐3p in autoreactive Th17 cell responses and suggest a potential therapeutic avenue for uveitis.—Wei, Y., Chen, S., Sun, D., Li, X., Wei, R., Li, X., Nian, H. miR‐223‐3p promotes autoreactive Th17 cell responses in experimental autoimmune uveitis (EAU) by inhibiting transcription factor FOXO3 expression. FASEB J. 33, 13951‐13965 (2019). www.fasebj.org
