Genomic factors underlying sex differences in trauma-related disorders.
Genomic factors underlying sex differences in trauma-related disorders.
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DOI：
10.1016/j.ynstr.2021.100330
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发表时间：
2021-05
影响因子：
5
通讯作者：
Ressler KJ
中科院分区：
文献类型：
--
作者：
Ponomareva OY;Ressler KJ
创伤后应激障碍（PTSD）是一种毁灭性的疾病，其治疗仅对大约一半的人口有效。这种有限的应答率强调了研究潜在的个体生物学机制的必要性，这些机制介导了这种疾病的发生和进展，从而确定了针对患者的治疗方法。PTSD在风险和症状模式上都有明显的性别差异。因此，一种方法是描述在治疗效果和对创伤反应方面表现出差异的男性和女性之间的创伤相关变化。最近测序技术的进步已经确定了几个与创伤后症状相关的基因组位点和转录变化。然而，尽管PTSD的诊断在女性中更为普遍，但性别差异背后的遗传因素仍然知之甚少。在这里，我们回顾了最近的工作，强调了目前对PTSD和相关症状的性别差异领域的理解和局限性。
Post-traumatic stress disorder (PTSD) is a devastating illness with treatment that is effective in only approximately half of the population. This limited rate of response highlights the necessity for research into underlying individual biological mechanisms that mediate development and progression of this disease, allowing for identification of patient-specific treatments. PTSD has clear sex differences in both risk and symptom patterns. Thus, one approach is to characterize trauma-related changes between men and women who exhibit differences in treatment efficacy and response to trauma. Recent technological advances in sequencing have identified several genomic loci and transcriptional changes that are associated with post-trauma symptomatology. However, although the diagnosis of PTSD is more prevalent in women, the genetic factors underlying sex differences remain poorly understood. Here, we review recent work that highlights current understanding and limitations in the field of sex differences in PTSD and related symptomatology.
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DOI：
10.1523/jneurosci.3021-09.2010
发表时间：
2010-01-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Goldstein JM;Jerram M;Abbs B;Whitfield-Gabrieli S;Makris N
通讯作者：
Makris N
影响因子：
5.6
作者：
Fenchel, Daphna;Levkovitz, Yechiel;Cohen, Hagit
通讯作者：
Cohen, Hagit
影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
25
作者：
Gelernter, Joel;Sun, Ning;Stein, Murray B.
通讯作者：
Stein, Murray B.
影响因子：
4.6
作者：
Breslau, Naomi;Anthony, James C.
通讯作者：
Anthony, James C.