Evidence for a glucuronic acid conjugate of N-hydroxy-4-aminobiphenyl in the urine of dogs given 4-aminobiphenyl.
Evidence for a glucuronic acid conjugate of N-hydroxy-4-aminobiphenyl in the urine of dogs given 4-aminobiphenyl.
复制标题
给予 4-氨基联苯的狗的尿液中存在 N-羟基-4-氨基联苯的葡萄糖醛酸结合物的证据。
作者：
J. Radomski;A. Rey;E. Brill
在给予4-氨基联苯的狗的尿液中获得了大量N -羟基-4-氨基联苯葡萄糖醛酸缀合物的证据。该缀合物具有很强的酸不稳定性，在较低的pH值和β-葡萄糖醛酸酶存在下容易释放游离的N -羟基-4-氨基联苯。尿中约25%的氚标记的4-氨基联苯排泄产物是由它产生的。它显然是先前在狗和猴子尿液中观察到的N -羟基化合物的来源，并被认为与4-氨基联苯诱导膀胱癌有关。
Summary Evidence of the presence of substantial quantities of a glucuronic acid conjugate of N -hydroxy-4-aminobiphenyl in the urine of dogs given 4-aminobiphenyl was obtained. The conjugate is very acid labile, readily liberating free N -hydroxy-4-aminobiphenyl at lowered pH and in the presence of β-glucuronidase. It was responsible for approximately 25% of the tritium-labeled excretory products of 4-aminibiphenyl in the urine. It is apparently the source of the N -hydroxy compound previously observed in dog and monkey urine and is believed to be involved in the induction of bladder cancer from 4-aminobiphenyl.