Visible-Light-Mediated β-C-H gem-Difluoroallylation of Aldehydes and Cyclic eKetones through C-F Bond Cleavage of 1-Trifluoromethyl Alkenes
Visible-Light-Mediated β-C-H gem-Difluoroallylation of Aldehydes and Cyclic eKetones through C-F Bond Cleavage of 1-Trifluoromethyl Alkenes
复制标题
通过 1-三氟甲基烯烃的 C-F 键断裂，可见光介导的醛和环酮的 β-C-H 宝石二氟烯丙基化。
DOI：
10.1021/acs.orglett.0c00568
复制
发表时间：
2020-03-20
期刊：
影响因子：
5.2
通讯作者：
Zhou, Lei
中科院分区：
文献类型：
--
作者：
Anand, Devireddy;Sun, Zhengchang;Zhou, Lei
含羰基的宝石-二氟烯烃是用常规方法合成的一个具有挑战性的目标。在这里，我们报告了一种温和而简洁的途径，通过可见光介导的脂肪醛和环酮的直接β - c - h gemi -二氟烯基化来获得目标化合物。在光氧化还原催化和有机催化的协同作用下，通过C-F键裂解，利用各种α - cf3烯烃作为宝石二氟烯丙基化试剂。
gem-Difluoroalkene bearing a carbonyl group is a challenging target to synthesize by conventional methods. Herein we report a mild and concise route to access the target compounds through the visible-light-mediated direct beta-C-H gem-difluoroallylation of aliphatic aldehydes and cyclic ketones. Upon a synergistic combination of photoredox catalysis and organocatalysis, various alpha-CF3 alkenes were employed as the gem-difluoroallylation reagents via the C-F bond cleavage.