A PROSPECTIVE-STUDY OF MODERATE ALCOHOL-CONSUMPTION AND THE RISK OF CORONARY-DISEASE AND STROKE IN WOMEN
A PROSPECTIVE-STUDY OF MODERATE ALCOHOL-CONSUMPTION AND THE RISK OF CORONARY-DISEASE AND STROKE IN WOMEN
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DOI：
10.1056/nejm198808043190503
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发表时间：
1988-08-04
影响因子：
158.5
通讯作者：
HENNEKENS, CH
中科院分区：
文献类型：
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作者：
STAMPFER, MJ;COLDITZ, GA;HENNEKENS, CH
1980年，87,526名年龄在34岁到59岁之间的女护士完成了一份饮食问卷，评估了她们对啤酒、葡萄酒和烈性酒的摄入量。到1984年，在334,382人年的随访中，我们记录了200例严重冠心病(164例非致死性心肌梗死，36例死于冠心病)，66例缺血性中风，28例蛛网膜下腔出血。随访率为98%。与不饮酒者相比，每天饮酒5-14克(每周3-9杯)的女性患冠心病的相对风险为0.6(95%可信区间为0.4-0.9)；每天饮酒15-24克的女性患冠心病的相对风险为0.6(0.3-1.1)，每天饮酒25克或以上的女性患冠心病的相对风险为0.4(0.2-0.8)。饮酒也与降低缺血性中风的风险有关。每天饮酒5至14克的相对风险为0.3(0.1至0.7)，每天饮酒15克或以上的相对风险为0.5(0.2至1.1)。相比之下，尽管蛛网膜下腔出血的病例数量很少，但酒精摄入往往与这种疾病的风险增加有关；每天摄入5至14克，相对风险为3.7(1.0至13.8)。这些前瞻性数据表明，在中年女性中，适度饮酒降低了冠心病和缺血性中风的风险，但可能会增加蛛网膜下腔出血的风险。
In 1980, 87,526 female nurses 34 to 59 years of age completed a dietary questionnaire that assessed their consumption of beer, wine, and liquor. By 1984, during 334,382 person-years of follow-up, we had documented 200 incident cases of severe coronary heart disease (164 nonfatal myocardial infarctions and 36 deaths due to coronary disease), 66 ischemic strokes, and 28 subarachnoid hemorrhages. Follow-up was 98 percent complete. As compared with nondrinkers, women who consumed 5 to 14 g of alcohol per day (three to nine drinks per week) had a relative risk of coronary disease of 0.6 (95 percent confidence interval, 0.4 to 0.9); for 15 to 24 g per day the relative risk was 0.6 (0.3 to 1.1), and for 25 g or more per day it was 0.4 (0.2 to 0.8), after adjustment for risk factors for coronary disease. Alcohol intake was also associated with a decreased risk of ischemic stroke. For 5 to 14 g of alcohol per day the relative risk was 0.3 (0.1 to 0.7), and for 15 g per day or more it was 0.5 (0.2 to 1.1). In contrast, although the number of cases of subarachnoid hemorrhage was small, alcohol intake tended to be associated with an increased risk of this disorder; for 5 to 14 g per day the relative risk was 3.7 (1.0 to 13.8). These prospective data suggest that among middle-aged women, moderate alcohol consumption decreases the risks of coronary heart disease and ischemic stroke but may increase the risk of subarachnoid hemorrhage.