Absence of bacteria in intracranial aneurysms
Absence of bacteria in intracranial aneurysms
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DOI：
10.3171/2018.12.jns183044
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发表时间：
2020-04-01
影响因子：
4.1
通讯作者：
Lejeune, Jean-Paul
中科院分区：
文献类型：
--
作者：
Aboukais, Rabih;Loiez, Caroline;Lejeune, Jean-Paul
目的 本研究旨在检测法国人群中未破裂和破裂动脉瘤壁中是否存在细菌。 方法 2018 年 1 月至 2018 年 7 月期间接受治疗的患者被纳入一项前瞻性研究，术中获取破裂或未破裂动脉瘤壁的标本。在同一手术过程中从每位患者身上采集颞浅动脉、硬脑膜和脑膜中动脉的样本，用作阴性对照。对每个样本进行直接细菌分析、需氧和厌氧细菌培养以及细菌 DNA 检测。 结果 有 21 名女性和 9 名男性，治疗时的平均年龄为 54 岁（范围 31-70 岁）。十八名患者是吸烟者。 18 名患者存在高血压，5 名患者存在高脂血症。 6名患者发现慢性酒精中毒。 1 名患者患有多囊肾病。 15 名患者患有多发性颅内动脉瘤。 10 名患者的动脉瘤破裂，20 名患者的动脉瘤未破裂。所有动脉瘤的平均直径为 8.5 毫米（范围 2.5-50 毫米）。通过直接细菌分析和培养，在任何样品中均未检测到细菌的存在。在所有样本中均未检测到细菌 DNA。 结论 与芬兰患者不同，法国患者的动脉瘤壁中未发现细菌存在。没有细菌感染可能解释了法国人群动脉瘤破裂风险低于芬兰人群的原因。
OBJECTIVE This study aimed to detect the presence of bacteria in the walls of both unruptured and ruptured aneurysms in a French population.METHODS Patients treated between January 2018 and July 2018 were included in a prospective study when specimens from ruptured or unruptured aneurysm walls were obtained intraoperatively. Samples from superficial temporal artery, dura mater, and middle meningeal artery were obtained from each patient during the same surgical procedure to be used as a negative control. Direct bacterial analysis, aerobic and anaerobic bacterial culture, and bacterial DNA detection were performed on each sample.RESULTS There were 21 women and 9 men with a mean age at treatment of 54 years (range 31-70 years). Eighteen patients were smokers. Hypertension was present in 18 patients and hyperlipidemia in 5 patients. Chronic alcoholism was found in 6 patients. Polycystic kidney disease was present in 1 patient. Fifteen patients had multiple intracranial aneurysms. Ten patients had a ruptured aneurysm and 20 had an unruptured aneurysm. The mean diameter of all aneurysms was 8.5 mm (range 2.5-50 mm). No presence of bacteria was detected with direct bacterial analysis and culture in any of the samples. No bacterial DNA was detected in any of the samples.CONCLUSIONS Unlike in Finnish patients, no bacterial presence was found in the wall of aneurysms in French patients. This absence of bacterial infection might explain the lower risk of aneurysm rupture in the French population compared to the Finnish population.