Differential expression of type XIV collagen/undulin by human mammary gland intralobular and interlobular fibroblasts
Differential expression of type XIV collagen/undulin by human mammary gland intralobular and interlobular fibroblasts
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DOI：
10.1007/s004410051020
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发表时间：
1998-03-01
影响因子：
3.6
通讯作者：
Gusterson, BA
中科院分区：
文献类型：
--
作者：
Atherton, AJ;Warburton, MJ;Gusterson, BA
人乳腺中XIV型胶原/波动蛋白的免疫定位显示小叶间质比小叶内间质沉积更多。小叶间质位于乳腺小叶与其相关的小叶间质之间。从小叶间质分离的成纤维细胞合成的XIV型胶原/波动蛋白比小叶内成纤维细胞多3- 5倍，但合成的I型和IV型胶原的量相似。在培养过程中，XIV型胶原/波动蛋白的差异表达得以维持，提示XIV型胶原/波动蛋白具有稳定致密胶原原纤维的作用。在乳腺的发育过程中，两种结构不同的基质的维持可能是重要的。
Immunolocalisation of type XIV collagen/undulin in the human mammary gland revealed greater deposition in the interlobular stroma than in the intralobular stroma. The interlobular stroma is located between the breast lobules and their associated intralobular stroma. Fibroblasts isolated from the interlobular stroma synthesised 3- to 5-fold more type XIV collagen/undulin than intralobular fibroblasts, but synthesised type I and type IV collagens in similar amounts. The differential expression of type XIV collagen/undulin was maintained with passage in culture, The results suggest a role for type XIV collagen/undulin in stabilising dense collagen fibrils. The maintenance of two types of structurally distinct stromas may be important during developmental processes in the mammary gland.