Silver cations fold i-motif at neutral pH

Silver cations fold i-motif at neutral pH
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DOI:
10.1039/c3cc43495h
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发表时间:
2013-01-01
影响因子:
4.9
通讯作者:
Waller, Zoe A. E.
Waller, Zoe A. E.
中科院分区:
化学2区
文献类型:
--
作者:
Day, Henry A.;Huguin, Camille;Waller, Zoe A. E.

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i-Motif DNA 结构之前已被用于许多不同的纳米技术应用,但所有应用都使用酸性条件来折叠 DNA。在此,我们描述了使用银阳离子在生理pH下折叠形成i-基序的DNA序列。随后的 DNA 解折叠可通过与半胱氨酸螯合来实现。
i-Motif DNA structures have previously been utilised formany different nanotechnological applications, but all have used acidic conditions to fold the DNA. Herein we describe the use of silver cations to fold an i-motif forming DNA sequence at physiological pH. Subsequent DNA unfolding can be achieved by chelation with cysteine.