Bifurcation model for characterization of pulmonary architecture
Bifurcation model for characterization of pulmonary architecture
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DOI：
10.1002/ar.20643
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发表时间：
2008-04-01
影响因子：
2
通讯作者：
Wexler, Anthony S.
中科院分区：
文献类型：
--
作者：
Lee, Dongyoub;Park, Seong S.;Wexler, Anthony S.
提出了不对称支气管气道分叉的灵活数学模型。用户指定几何参数后自动确定分叉结构：母气道半径、子气道半径、子支环曲率半径、分叉角度、隆凸脊曲率半径。三个气道合并区域的详细形状由几个显式函数定义，并且可以根据观察到的肺部结构轻松更改。这些函数考虑了隆突的钝形状、从外部过渡区到内部过渡区的平滑过渡以及作为分叉不对称函数的隆突脊起始位置的移动。我们通过将分叉模型与大鼠肺铸型的计算机断层扫描图像进行比较来验证分叉模型。分叉几何形状的三维表示可以在 http://mae.ucdavis.edu/wexler/lungs/bifurc.htm 上查看。
A flexible mathematical model of an asymmetric bronchial airway bifurcation is presented. The bifurcation structure is automatically determined after the user specifies geometric parameters: radius of parent airway, radii of daughter airways, radii of curvature of the daughter branch toroids, bifurcation angles, and radius of curvature of carina ridge. Detailed shape in the region where the three airways merge is defined by several explicit functions and can be changed with ease in accordance with observed lung structure. These functions take into account the blunt shape of the carina, the smooth transition from the outer transition zone to the inner one, and the shift in carinal ridge starting position as a function of bifurcation asymmetry. We validated the bifurcation model by comparing it to a computed tomography image of a rat lung cast. Three-dimensional representations of the bifurcation geometry can be viewed at http://mae.ucdavis.edu/wexler/lungs/bifurc.htm.