Health-related quality of life profiles based on survivorship status for head and neck cancer patients
Health-related quality of life profiles based on survivorship status for head and neck cancer patients
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DOI：
10.1002/hed.20507
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发表时间：
2007-03-01
影响因子：
2.9
通讯作者：
Funk, Gerry F.
中科院分区：
文献类型：
--
作者：
Goldstein, David P.;Karnell, Lucy Hynds;Funk, Gerry F.
背景。随着头颈癌患者健康相关生活质量（HRQOL）评估方法在过去10年中趋于成熟，对纵向数据报告的关注日益增加。这些研究主要集中在长期幸存者，本研究解决了长期和短期幸存者的HRQOL。这是一项对479名头颈癌患者进行的前瞻性、纵向研究，在确诊后随访至少3年。分析纵向收集的HRQOL评分是基于生存状态。3个生存组：短期（死亡< 1年）、中期（死亡1-3年）和长期（存活1-3年）的HRQOL在各时间点（预处理、3个月、6个月和12个月）均不同。短期和长期幸存者之间的差异最大。长期幸存者在12个月时表现出最佳的HRQOL和改善的HRQOL轨迹。在所有可用的随访中，短期幸存者的HRQOL急剧下降。中期幸存者在治疗后确实表现出一些改善，但在12个月时HRQOL轨迹下降。不同生存状态的头颈癌患者的HRQOL差异显著。长期HRQOL结果应在所有符合纳入初始研究队列的患者结果的背景下进行分析。(c) 2006 Wiley期刊公司
Background. As the methodologies for evaluating health-related quality of life (HRQOL) in head and neck cancer patients have matured over the past 10 years, there has been an increasing focus on reporting longitudinal data. These studies have primarily focused on long-term survivors, This study addresses the HRQOL of both long-term and short-term survivors.Methods. This is a prospective, longitudinal study of 479 head and neck cancer patients followed for at least 3 years after diagnosis. Analysis of longitudinally collected HRQOL scores was based on survivorship status.Results. The HRQOL for 3 survivorship groups: short-term (died < 1 year), intermediate-term (died 1-3 years), and long-term survivors (alive > 3 years) were different at all time points (pretreatment, 3, 6, and 12 months). Differences were greatest between the short-term and long-term survivors. Long-term survivors demonstrated the best HRQOL and an improving HRQOL trajectory at 12 months. The HRQOL of short-term survivors declined precipitously throughout all available follow-up. Intermediate-term survivors did show some improvement following treatment but had a declining HRQOL trajectory at 12 months.Conclusion. The HRQOL profiles of head and neck cancer patients differed significantly depending on survivorship status. Long-term HRQOL results should be analyzed within the context of the results for all of the patients eligible to have been included in the initial study cohort. (c) 2006 Wiley Periodicals, Inc.