Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy
Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy
复制标题
巨噬细胞-癌症混合膜包被纳米粒子用于乳腺癌治疗中的肺转移靶向
DOI：
10.1186/s12951-020-00649-8
复制
发表时间：
2020-06-16
影响因子：
10.2
通讯作者：
Yuan, Yongfang
中科院分区：
文献类型：
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作者：
Gong, Chunai;Yu, Xiaoyan;Yuan, Yongfang
细胞膜覆盖的药物递送纳米平台由于其来源于源细胞的增强的生物界面能力而一直受到关注。在这种自上而下的技术中，纳米颗粒（NP）被各种膜涂层覆盖，包括来自专门细胞的膜或混合膜，其联合收割机结合了不同类型细胞膜的能力。在此，通过融合来自RAW 264.7（RAW）和4 T1细胞（4 T1）的膜组分来制造杂化膜涂覆的阿霉素（Dox）负载的聚（乳酸-共-乙醇酸）（PLGA）NP（DPLGA@[RAW-4 T1] NP）。这些NP用于治疗源自乳腺癌的肺转移。该研究表明，NPs与来自巨噬细胞和癌细胞的杂合膜的偶联具有几个优点，例如在炎症部位积累的倾向、靶向特异性转移的能力、体外均质肿瘤靶向能力以及体内肺转移模型中显著增强的多靶点能力。DPLGA@[RAW-4 T1] NP在治疗乳腺癌来源的肺转移后表现出优异的化疗潜力，具有约88.9%的抗转移功效。这些纳米颗粒是稳健的，并显示出杂化膜的多靶向能力。本研究为乳腺癌转移的有效治疗提供了一个有前景的仿生纳米平台。
Cell membrane- covered drug-delivery nanoplatforms have been garnering attention because of their enhanced bio-interfacing capabilities that originate from source cells. In this top-down technique, nanoparticles (NPs) are covered by various membrane coatings, including membranes from specialized cells or hybrid membranes that combine the capacities of different types of cell membranes. Here, hybrid membrane-coated doxorubicin (Dox)-loaded poly(lactic-co-glycolic acid) (PLGA) NPs (DPLGA@[RAW-4T1] NPs) were fabricated by fusing membrane components derived from RAW264.7(RAW) and 4T1 cells (4T1). These NPs were used to treat lung metastases originating from breast cancer. This study indicates that the coupling of NPs with a hybrid membrane derived from macrophage and cancer cells has several advantages, such as the tendency to accumulate at sites of inflammation, ability to target specific metastasis, homogenous tumor targeting abilities in vitro, and markedly enhanced multi-target capability in a lung metastasis model in vivo. The DPLGA@[RAW-4T1] NPs exhibited excellent chemotherapeutic potential with approximately 88.9% anti-metastasis efficacy following treatment of breast cancer-derived lung metastases. These NPs were robust and displayed the multi-targeting abilities of hybrid membranes. This study provides a promising biomimetic nanoplatform for effective treatment of breast cancer metastasis.