Mitochondrial DNA 5178 C/A polymorphism influences the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men.
Mitochondrial DNA 5178 C/A polymorphism influences the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men.
复制标题
线粒体 DNA 5178 C/A 多态性影响习惯性吸烟对日本中年男性血脂异常风险的影响。
DOI：
10.1186/1476-511x-11-97
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发表时间：
2012-08-02
影响因子：
4.5
通讯作者：
Takashima Y
中科院分区：
文献类型：
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作者：
Kokaze A;Ishikawa M;Matsunaga N;Karita K;Yoshida M;Shimada N;Ohtsu T;Shirasawa T;Ochiai H;Satoh M;Hashimoto M;Hoshino H;Takashima Y
据报道，几种遗传多态性改变了吸烟对血脂水平的影响。本研究的目的是调查长寿相关的线粒体DNA 5178（Mt5178）C/A多态性是否改变习惯性吸烟对中年日本受试者血脂异常风险的影响。从定期到医院进行体检的个体中选择了共计394名男性受试者（年龄，53.9 ± 7.9岁;平均值± SD）。在Mt5178 C/A基因分型后，进行了一项横断面研究，评估Mt5178 C/A多态性和吸烟对低高密度脂蛋白（HDL）胆固醇血症、高低密度脂蛋白（LDL）胆固醇血症或高胆固醇血症风险的联合影响。对于Mt5178 C受试者，低HDL胆固醇血症的风险随着每日吸烟数量的增加而增加（趋势P = 0.001）。另一方面，Mt5178 A基因型与低HDL胆固醇血症风险之间的关联似乎并不依赖于每天吸烟的数量。对于Mt5178 A患者，高LDL胆固醇血症或高胆固醇血症的风险随着每日吸烟而增加（趋势P = 0.017，趋势P = 0.002）。然而，Mt5178 C基因型与高LDL胆固醇血症或高胆固醇血症风险之间的关联并不依赖于每天吸烟的数量。目前的研究结果表明，Mt5178 C/A多态性调节习惯性吸烟对中年日本男性血脂异常风险的影响。
Several genetic polymorphisms have been reported to modify the effects of smoking on serum lipid levels. The objective of this study was to investigate whether longevity-associated mitochondrial DNA 5178 (Mt5178) C/A polymorphism modifies the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese subjects. A total of 394 male subjects (age, 53.9 ± 7.9 years; mean ± SD) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, a cross-sectional study assessing the joint effect of Mt5178 C/A polymorphism and cigarette smoking on the risk of hypo-high-density lipoprotein (HDL) cholesterolemia, hyper-low-density lipoprotein (LDL) cholesterolemia or hypertriglyceridemia was conducted. For subjects with Mt5178C, the risk of hypo-HDL cholesterolemia increased with the number of cigarettes smoked daily (P for trend = 0.001). On the other hand, the association between Mt5178A genotype and the risk of hypo-HDL cholesterolemia did not appear to depend on the number of cigarettes smoked daily. For those with Mt5178A, the risk of hyper-LDL cholesterolemia or hypertriglyceridemia increased with cigarettes smoked daily (P for trend = 0.017 and P for trend = 0.002, respectively). However, the association between Mt5178C genotype and the risk of hyper-LDL cholesterolemia or hypertriglyceridemia did not depend on the number of cigarettes smoked daily. The present results suggest that Mt5178 C/A polymorphism modulates the effects of habitual smoking on the risk of dyslipidemia in middle-aged Japanese men.