ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes
ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes
复制标题
DOI：
10.1093/nar/gkh355
复制
发表时间：
2004-07-01
影响因子：
14.9
通讯作者：
Stubbs, L
中科院分区：
文献类型：
--
作者：
Ovcharenko, I;Nobrega, MA;Stubbs, L
随着越来越多的脊椎动物基因组以草图或成品的形式测序，通过比较基因组比对来解码DNA序列语言的独特机会已经出现。然而，需要新的工具和策略来容纳大量的基因组信息，并促进将比较序列比对产生的预测转移给专注于基因组功能实验注释的研究人员。在这里，我们提出了ECR浏览器，一个工具，提供了简单和动态访问全基因组比对的人类，小鼠，大鼠和鱼类序列。这个基于网络的工具（http://ecrbrowser.dcode.org）为发现新基因、鉴定远端基因调控元件和预测转录因子结合位点提供了起点。ECR浏览器的基因组比对门户还允许对任何用户提交的序列进行快速和自动的比对。ECR浏览器与其他DNA序列分析工具的互连为研究和探索脊椎动物基因组创造了一个独特的门户。
With an increasing number of vertebrate genomes being sequenced in draft or finished form, unique opportunities for decoding the language of DNA sequence through comparative genome alignments have arisen. However, novel tools and strategies are required to accommodate this large volume of genomic information and to facilitate the transfer of predictions generated by comparative sequence alignment to researchers focused on experimental annotation of genome function. Here, we present the ECR Browser, a tool that provides easy and dynamic access to whole genome alignments of human, mouse, rat and fish sequences. This web-based tool (http://ecrbrowser.dcode.org) provides the starting point for discovery of novel genes, identification of distant gene regulatory elements and prediction of transcription factor binding sites. The genome alignment portal of the ECR Browser also permits fast and automated alignments of any user-submitted sequence to the genome of choice. The interconnection of the ECR Browser with other DNA sequence analysis tools creates a unique portal for studying and exploring vertebrate genomes.