Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury.
Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury.
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DOI：
10.1038/nn.4289
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发表时间：
2016-06
影响因子：
25
通讯作者：
Yoshida Y
中科院分区：
文献类型：
--
作者：
Ueno M;Ueno-Nakamura Y;Niehaus J;Popovich PG;Yoshida Y
Spinal cord injury (SCI) at high spinal levels (e.g., above thoracic level 5) causes systemic immune suppression; however, the underlying mechanisms are unknown. Here, we show that profound plasticity develops within spinal autonomic circuitry below the injury, creating a sympathetic anti-inflammatory reflex, and that chemogenetic silencing of this reflex circuitry blocks post-SCI immune suppression. These data provide new insights and potential therapeutic options for limiting the devastating consequences of post-traumatic autonomic hyperreflexia and post-injury immune suppression.
