S1 nerve is the most efficient nerve rootlet innervating the anal canal and rectum in rats.
S1 nerve is the most efficient nerve rootlet innervating the anal canal and rectum in rats.
复制标题
S1神经是支配大鼠肛管和直肠的最有效的神经根。
DOI：
10.1038/srep13022
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发表时间：
2015-08-11
影响因子：
4.6
通讯作者：
Chai Y
中科院分区：
文献类型：
--
作者：
Fu K;Luo P;Zheng X;Zhu X;Wang L;Chai Y
自主神经和躯体成分参与哺乳动物的排便过程，结合脑干和前脑的信号。大鼠排尿的神经支配模式已经得到了很好的研究，而排便的研究较少。本研究的目的是确定肛管和直肠中与排便有关的最重要的感觉神经和运动神经。刺激L6和S1腹侧根时，肛管和直肠诱发电位的波幅高于其他节段(ANOVA和TUKEY‘s POST检验，均P <； 0.0 5)。与其他片段相比，S1片段的霍乱毒素B亚基与辣根过氧化物酶结合更强(方差分析和图基后检验，P <； 0.0 5)。电刺激L5~S3腹侧脊神经根时，L6和S1的腹侧脊神经根主要引起肛管和直肠的压力变化。总之，许多传入和传出神经支配肛管和直肠，并参与排便，但S1神经根可能是最有效的神经根。这些结果可为排便重建，特别是脊髓损伤患者的排便重建提供依据。
Autonomic and somatic components participate in the defecation process in mammals, combining signals from the brainstem and forebrain. The innervation pattern involved in micturition in rats has been well studied, while defecation has been less studied. The aim of the present study was to identify the most important sensory and motor nerves of the anal canal and rectum involved in defecation. The amplitudes of evoked potential of the anal canal and rectum were higher when L6 and S1 ventral rootlets were stimulated, compared with the other segments (ANOVA and Tukey’s post hoc test, all P < 0.05). The S1 segment was more strongly cholera toxin subunit B conjugated to horseradish peroxidase (CB-HRP) positive compared with the other segments (ANOVA and Tukey’s post hoc test, P < 0.05). Ventral spinal rootlets of L6 and S1 mainly contributed to the pressure change in the anal canal and rectum when the ventral spinal rootlets from L5 to S3 were stimulated electrically. In conclusion, many afferent and efferent nerves innervate the anal canal and rectum and are involved in defecation, but the S1 nerve rootlet could be the most efficient one. These results could provide a basis for defecation reconstruction, especially for patients with spinal cord injuries.