New classification and diagnostic criteria for insulin resistance syndrome
New classification and diagnostic criteria for insulin resistance syndrome
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DOI：
10.1507/endocrj.ej21-0725
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发表时间：
2022-01-31
影响因子：
2.2
通讯作者：
Katagiri, Hideki
中科院分区：
文献类型：
--
作者：
Ogawa, Wataru;Araki, Eiichi;Katagiri, Hideki
日本糖尿病学会成立的工作组的这份报告提出了胰岛素抵抗综合征的新分类和诊断标准。胰岛素抵抗综合征是指由于胰岛素受体或其下游信号分子的功能受损而导致胰岛素作用严重减弱的疾病。这种综合征分为两种类型：由基因异常引起的遗传性胰岛素抵抗综合征和由胰岛素受体自身抗体引起的B型胰岛素抵抗综合征。遗传性胰岛素抵抗综合征包括A型胰岛素抵抗以及Donohue和Rabson-Mendenhall综合征，所有这些都是由胰岛素受体基因异常引起的;由PIK 3R 1异常引起的病症，如SHORT综合征，其编码磷脂酰肌醇3-激酶的调节亚基;由AKT 2、TBC 1D 4或PRKCE异常引起的病症;以及致病基因尚未被鉴定的病症。B型胰岛素抵抗综合征的特征是由于存在胰岛素受体自身抗体而导致胰岛素作用严重受损。单纯由刺激胰岛素受体的自身抗体引起的低血糖症不包括在B型胰岛素抵抗综合征中。日本糖尿病学会成立的工作组的这份报告提出了胰岛素抵抗综合征的新分类和诊断标准。胰岛素抵抗综合征是指由于胰岛素受体或其下游信号分子的功能受损而导致胰岛素作用严重减弱的疾病。这种综合征分为两种类型：由基因异常引起的遗传性胰岛素抵抗综合征和由胰岛素受体自身抗体引起的B型胰岛素抵抗综合征。遗传性胰岛素抵抗综合征包括A型胰岛素抵抗以及Donohue和Rabson-Mendenhall综合征，所有这些都是由胰岛素受体基因异常引起的;由PIK 3R 1异常引起的病症，如SHORT综合征，其编码磷脂酰肌醇3-激酶的调节亚基;由AKT 2、TBC 1D 4或PRKCE异常引起的病症;以及致病基因尚未被鉴定的病症。B型胰岛素抵抗综合征的特征是由于存在胰岛素受体自身抗体而导致胰岛素作用严重受损。仅由刺激胰岛素受体的自身抗体诱导的低血糖病例不包括在B型胰岛素抵抗综合征中。
This report of a working group established by the Japan Diabetes Society proposes a new classification and diagnostic criteria for insulin resistance syndrome. Insulin resistance syndrome is defined as a condition characterized by severe attenuation of insulin action due to functional impairment of the insulin receptor or its downstream signaling molecules. This syndrome is classified into two types: genetic insulin resistance syndrome, caused by gene abnormalities, and type B insulin resistance syndrome, caused by autoantibodies to the insulin receptor. Genetic insulin resistance syndrome includes type A insulin resistance as well as Donohue and Rabson-Mendenhall syndromes, all of which are caused by abnormalities of the insulin receptor gene; conditions such as SHORT syndrome caused by abnormalities of PIK3R1, which encodes a regulatory subunit of phosphatidylinositol 3-kinase; conditions caused by abnormalities of AKT2, TBC1D4, or PRKCE; and conditions in which a causative gene has not yet been identified. Type B insulin resistance syndrome is characterized by severe impairment of insulin action due to the presence of insulin receptor autoantibodies. Cases in which hypoglycemia alone is induced by autoantibodies that stimulate insulin receptor were not included in Type B insulin resistance syndrome.This report of a working group established by the Japan Diabetes Society proposes a new classification and diagnostic criteria for insulin resistance syndrome. Insulin resistance syndrome is defined as a condition characterized by severe attenuation of insulin action due to functional impairment of the insulin receptor or its downstream signaling molecules. This syndrome is classified into two types: genetic insulin resistance syndrome, caused by gene abnormalities, and type B insulin resistance syndrome, caused by autoantibodies to the insulin receptor. Genetic insulin resistance syndrome includes type A insulin resistance as well as Donohue and Rabson-Mendenhall syndromes, all of which are caused by abnormalities of the insulin receptor gene; conditions such as SHORT syndrome caused by abnormalities of PIK3R1, which encodes a regulatory subunit of phosphatidylinositol 3-kinase; conditions caused by abnormalities of AKT2, TBC1D4, or PRKCE; and conditions in which a causative gene has not yet been identified. Type B insulin resistance syndrome is characterized by severe impairment of insulin action due to the presence of insulin receptor autoantibodies. Cases in which hypoglycemia alone is induced by autoantibodies that stimulate insulin receptor were not included in Type B insulin resistance syndrome.