Expression and prognostic significance of VEGFR-2 in breast cancer
Expression and prognostic significance of VEGFR-2 in breast cancer
复制标题
VEGFR-2 在乳腺癌中的表达及其预后意义。
DOI：
10.1016/j.prp.2015.04.003
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发表时间：
2015-01-01
影响因子：
2.8
通讯作者：
Hu, Yue-Ming
中科院分区：
文献类型：
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作者：
Yan, Ji-Dong;Liu, Yanrong;Hu, Yue-Ming
乳腺癌是世界上妇女最常见的癌症之一。血管内皮生长因子受体2（Vascular endothelial growth factor receptor 2，VEGFR-2）不仅在肿瘤血管生成中起关键作用，而且在多种肿瘤的肿瘤细胞中均有表达。本研究通过检测乳腺癌组织中VEGFR-2的表达情况，探讨其在乳腺癌预后中的作用。应用免疫组化方法检测98例浸润性乳腺癌组织中VEGFR-2的表达和定位。分析VEGFR-2表达与临床病理特征的关系。结果表明，VEGFR-2表达与乳腺癌淋巴结转移呈正相关。VEGFR-2高表达的乳腺癌组织中上皮间质转化（EMT）标志物Twist 1和Vimentin的表达均高于低表达的乳腺癌组织，而E-cadherin的表达则低于低表达的乳腺癌组织，提示VEGFR-2可能是乳腺癌EMT的一种介导因子。(C)2015爱思唯尔有限公司All rights reserved.
Breast cancer is one of the most common cancers among women in the world. Vascular endothelial growth factor receptor 2 (VEGFR-2) was not only found to play a key role in the development of tumor angiogenesis, but has also been located in tumor cells of a variety of tumors. This study investigated the expression pattern of VEGFR-2 in breast cancer tissue specimens in order to evaluate the role of VEGFR-2 in the prognosis of breast cancer. Expression and localization of VEGFR-2 in tumor cells of breast cancer specimens from 98 invasive breast cancer patients were determined by immunohistochemistry. The relationships between VEGFR-2 expression and clinicopathological features were also analyzed. The results showed that VEGFR-2 expression correlated positively with lymph node (LN) metastasis of breast cancer. Patients with high expression of VEGFR-2 had a significantly worse OS. It was also observed that the expression of epithelial-mesenchymal transition (EMT) marker, including Twist1 and Vimentin, was higher in the tumors with higher VEGFR-2 expression, while the E-cadherin expression was lower in the same tumors, suggesting that VEGFR-2 may serve as a possible mediator of EMT in breast cancer. (C) 2015 Elsevier GmbH. All rights reserved.