Histopathologic features and risk factors for benignity, hyperplasia, and cancer in endometrial polyps
Histopathologic features and risk factors for benignity, hyperplasia, and cancer in endometrial polyps
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DOI：
10.1067/mob.2003.247
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发表时间：
2003-04-01
影响因子：
9.8
通讯作者：
Bovicelli, L
中科院分区：
文献类型：
--
作者：
Savelli, L;De Iaco, P;Bovicelli, L
目的：探讨良性、增生性和恶性子宫内膜息肉的发生率，以及临床资料能否预测组织病理学结果。研究设计：从我们的妇科外科数据库中筛选出509例子宫内膜息肉患者，这些患者在宫腔镜下连续48个月以上行子宫内膜息肉切除术。医疗报告提供了临床数据。结果：组织学上良性息肉358例(70.3%)，单纯或复杂子宫内膜增生症131例(25.7%)，增生伴非典型性息肉16例(3.1%)，癌性息肉4例(0.8%)。根据息肉的恶性程度分为A组和B组(A组为良性；B组为不典型增生和癌变)。年龄、绝经状况和高血压与B组显著相关。结论：子宫内膜息肉很少恶变，但增生性改变更常见。年龄、绝经状态和高血压可能会增加癌前病变和恶性息肉的风险。为了达到完全切除息肉和可靠的组织学分析，应该提供手术宫腔镜术。对有症状的患者或有危险因素的患者。
OBJECTIVE: The purpose of this study was to determine the rate of benign, hyperplastic, and malignant endometrial polyps and whether clinical data can predict histopathologic outcome.STUDY DESIGN: Five hundred nine patients with endometrial polyps who consecutively underwent hysteroscopic removal of endometrial polyps over 48 months were identified from our gynecologiconcology surgical database. Medical reports provided clinical data. Statistical analysis was performed.RESULTS: Histologically, 358 polyps (70.3%) were benign; 131 polyps (25.7%) had simple or complex endometrial hyperplasia, 16 polyps (3.1%) had hyperplasia with atypia, and 4 polyps (0.8%) were cancerous. Polyps were divided into group A and group B, according to the risk of malignancy (group A, benign; group B, atypical hyperplastic and cancerous). Age, menopause status, and hypertension were associated significantly with group B.CONCLUSION: Endometrial polyps rarely become malignant, but hyperplastic changes are more common. Age, menopause status, and hypertension may increase the risk of premalignant and malignant polyps. To achieve complete removal of the polyp and a reliable histologic analysis, operative hysteroscopy should be offered to. symptomatic patients or to patients with risk factors.