Association of Serum Triglycerides With Arterial Stiffness in Subjects With Low Levels of Low-Density Lipoprotein Cholesterol
Association of Serum Triglycerides With Arterial Stiffness in Subjects With Low Levels of Low-Density Lipoprotein Cholesterol
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DOI：
10.1253/circj.cj-18-0607
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发表时间：
2018-12-01
影响因子：
3.3
通讯作者：
Kawakami, Koji
中科院分区：
文献类型：
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作者：
Kawasoe, Shin;Ide, Kazuki;Kawakami, Koji
背景：血清甘油三酯(TG)水平作为心血管危险因素的独立作用仍未阐明。我们的目的是研究血清低密度脂蛋白胆固醇(LDL-C)水平是否影响甘油三酯对动脉僵硬的影响。方法和结果：我们研究了11640名健康体检的受试者。按低密度脂蛋白胆固醇水平(=160 mg/dL)分为4组。采用臂踝脉搏波速度(BaPWV)评价动脉僵硬程度。采用单因素和多因素Logistic回归分析探讨高甘油三酯(>；=150 mg/dL)与高BaPWV(>；1400 cm/S)之间的关系。在单变量分析中，高甘油三酯与高低密度脂蛋白胆固醇的baPWV显著相关
Background: The independent role of serum triglyceride (TG) levels as a cardiovascular risk factor is still not elucidated. We aimed to investigate if the effect of TG on arterial stiffness is influenced by the serum level of low-density lipoprotein cholesterol (LDL-C).Methods and Results: We studied 11,640 subjects who underwent health checkups. They were stratified into 4 groups according to LDL-C level (= 160 mg/dL). Arterial stiffness was evaluated by brachial-ankle pulse wave velocity (baPWV). In each group, univariate and multivariete logistic regression analyses were performed to investigate the association between high TG (>= 150 mg/dL) and high baPWV (>1,400 cm/s). In the univarite analysis, high TG was significantly associated with high baPWV in LDL-C