Highly Bactericidal Macroporous Antimicrobial Polymeric Gel for Point-of-Use Water Disinfection.
Highly Bactericidal Macroporous Antimicrobial Polymeric Gel for Point-of-Use Water Disinfection.
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DOI：
10.1038/s41598-018-26202-0
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发表时间：
2018-05-21
影响因子：
4.6
通讯作者：
Wong EHH
中科院分区：
文献类型：
--
作者：
Kumar A;Boyer C;Nebhani L;Wong EHH
在许多发展中国家，清洁和安全的供水仍然不足。其中一个关键挑战是通过有效的水消毒技术从供水中去除致病菌，以防止疾病传播并确保消费者的安全。在本文中，展示了一种高效的使用点（按需）水消毒技术，其形式为称为大孔抗菌聚合物凝胶（MAPG）的聚合物支架。MAPG易于制造，完全是有机的，并具有固有的抗菌性能，这使得它不依赖于银等无机化合物，而银等无机化合物的长期毒性仍然未知。MAPG具有高度杀菌性，可以对被细菌污染的水进行消毒（约。108 CFU mL-1），在处理20分钟内灭活>99%的革兰氏阴性和革兰氏阳性细菌，包括大肠杆菌、霍乱弧菌和金黄色葡萄球菌。当在注射器中制造时，MAPG消除E.大肠杆菌从污染水源中的细菌计数减少>8.0 log 10（即，处理后没有检测到活细菌），并且注射器可以重复使用多次而不损失效力。MAPG技术不仅限于水消毒，还可应用于其他细菌灭活应用。
Access to clean and safe water supply remains inadequate in many developing countries. One of the key challenges is to remove pathogenic bacteria from the water supply via effective water disinfection technologies to prevent the spread of diseases and to ensure the safety of consumers. Herein, a highly effective point-of-use (on-demand) water disinfection technology, in the form of a polymeric scaffold called macroporous antimicrobial polymeric gel (MAPG), is demonstrated. MAPG is easy to fabricate, completely organic and possess inherent antimicrobial property which makes it non-reliant on inorganic compounds such as silver where the long-term toxicity remains unknown. MAPG is highly bactericidal and can disinfect bacteria-contaminated water (ca. 108 CFU mL−1) at a capacity of about >50 times the mass of the organic material used, inactivating >99% of both Gram-negative and Gram-positive bacteria including Escherichia coli, Vibrio cholerae and Staphylococcus aureus within 20 minutes of treatment. When fabricated in a syringe, MAPG eliminates E. coli from contaminated water source by >8.0 log10 reduction in bacteria counts (i.e., no viable bacteria were detected after treatment), and the syringe can be reused multiple times without losing potency. The MAPG technology is not only restricted to water disinfection but may also be applicable in other bacteria inactivation applications.
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影响因子：
64.8
作者：
Sun, Jeong-Yun;Zhao, Xuanhe;Illeperuma, Widusha R. K.;Chaudhuri, Ovijit;Oh, Kyu Hwan;Mooney, David J.;Vlassak, Joost J.;Suo, Zhigang
通讯作者：
Suo, Zhigang
影响因子：
16.6
作者：
通讯作者：
--
影响因子：
--
作者：
Mansouri, Jaleh;Harrisson, Simon;Chen, Vicki
通讯作者：
Chen, Vicki
影响因子：
9.5
作者：
Pan, Jill Ruhsing;Su, Yu-Chun;Lee, Hsin-Chieh
通讯作者：
Lee, Hsin-Chieh
影响因子：
5.3
作者：
Thuy-Khanh Nguyen;Lam, Shu Jie;Wong, Edgar H. H.
通讯作者：
Wong, Edgar H. H.