Non-lethal roles of the initiator caspase Dronc in Drosophila
Non-lethal roles of the initiator caspase Dronc in Drosophila
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DOI：
10.3389/fceld.2023.1184041
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发表时间：
2023-04
期刊：
影响因子：
3.7
通讯作者：
Daniel Domínguez;Yun Fan
中科院分区：
文献类型：
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作者：
Daniel Domínguez;Yun Fan
半胱天冬酶或半胱氨酸-天冬氨酸蛋白酶在细胞凋亡中的作用已经在多种生物体中得到了充分的研究。这些凋亡的半胱天冬酶可分为启动子和效应子半胱天冬酶，前者裂解并激活后者以触发细胞死亡。然而，新出现的证据支持半胱天冬酶在发育、组织稳态和疾病中的非致命作用。与效应型半胱天冬酶相比，启动型半胱天冬酶的非凋亡功能知之甚少，因为它们的活性更受限制，已知的底物更少。本文综述了近年来在果蝇中发现的caspase Dronc的非致死作用。我们讨论了它们的生物学重要性，潜在的调控机制，以及对我们理解它们的哺乳动物对应物的影响。解密Dronc的非凋亡功能将为caspase在发育过程中和包括癌症在内的疾病中的多方面功能提供有价值的见解。
The role of caspases, or cysteine-aspartic proteases, in apoptosis has been well-studied across multiple organisms. These apoptotic caspases can be divided into initiator and effector caspases, with the former cleaving and activating the latter to trigger cell death. However, emerging evidence is supporting non-lethal roles of caspases in development, tissue homeostasis and disease. In comparison to effector caspases, less is known about the non-apoptotic functions of initiator caspases because of their more restricted activities and fewer known substrates. This review focuses on some recent findings in Drosophila on non-lethal roles of the initiator caspase Dronc. We discuss their biological importance, underlying regulatory mechanisms, and implications for our understanding of their mammalian counterparts. Deciphering the non-apoptotic functions of Dronc will provide valuable insights into the multifaceted functions of caspases during development and in diseases including cancer.