Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene val158/108Met polymorphism
Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene val158/108Met polymorphism
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DOI：
10.1016/j.biopsych.2008.01.005
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发表时间：
2008-07-15
影响因子：
10.6
通讯作者：
Munafo, Marcus R.
中科院分区：
文献类型：
--
作者：
Barnett, Jennifer H.;Scoriels, Linda;Munafo, Marcus R.
背景资料：认知内表型可能会进一步加深我们对精神疾病遗传基础的理解，而儿茶酚-O-甲基转移酶（COMT）基因是一个有前途的候选基因，既认知功能和障碍。我们进行了荟萃分析的COMT Val 158/108 Met多态性和记忆和执行functions.Methods措施之间的关联报告：PubMed数据库进行了搜索有关认知功能和COMT Val 158/108 Met多态性的研究。这使得对六种认知表型（连线任务、言语回忆、言语流畅性、智商得分、n-back任务和威斯康星州卡片分类测试）的荟萃分析成为可能。数据提取由两名评论员，包括认知得分的COMT基因型，出版年份，诊断状态，祖先，男性参与者的比例，以及基因型频率是否符合Hardy-Weinberg equilibrium.Results：我们发现COMT基因型和大多数表型之间没有关联。有证据表明，与智商得分（d = 0.06），这并没有显着差异的祖先，性别，平均样本年龄，或病人的状态。对于n-back任务，没有强有力的证据表明遗传相关，但患者群体（d = 0.40）的效应量显着大于非患者群体（d =-0.27），并且在男性受试者较少的两个样本中效应量都较大，以及平均年龄较大的样本。也有证据表明，出版偏见和降低效应大小与后来publication.Conclusions：尽管最初有希望的结果，COMT Val 58/108 Met多态性似乎有很少的，如果任何关联与认知功能。发表偏见可能会阻碍理解心理功能和精神疾病的遗传基础的尝试。
Background: Cognitive endophenotypes may further our understanding of the genetic basis of psychiatric disorders, and the catechol-O-methyltransferase (COMT) gene is a promising candidate gene for both cognitive function and disorder. We conducted a meta-analysis of reported associations between the COMT Val158/108Met polymorphism and measures of memory and executive function.Methods: The PubMed database was searched for studies relating cognitive functions and the COMT Val158/108Met polymorphism. This enabled meta-analyses of six cognitive phenotypes (Trail Making task, verbal recall, verbal fluency, IQ score, n-back task, and Wisconsin Card Sorting Test). Data were extracted by two reviewers and included cognitive scores by COMT genotype, publication year, diagnostic status, ancestry, proportion of male participants, and whether genotype frequencies were consistent with Hardy-Weinberg equilibrium.Results: We found no association between COMT genotype and the majority of phenotypes. There was evidence of association with IQ score (d = .06), which did not differ significantly by ancestry, sex, average sample age, or patient status. For the n-back task, there was no robust evidence for genetic association, but the effect size was significantly larger in patient (d = .40) than nonpatient (d = -.27) populations, larger in both samples with fewer male subjects, and those of greater average age. There was also evidence of publication bias and decreasing effect sizes with later publication.Conclusions: Despite initially promising results, the COMT Val58/108Met polymorphism appears to have little if any association with cognitive function. Publication bias may hamper attempts to understand the genetic basis of psychological functions and psychiatric disorders.