Preparation and Characterization of Lanthanum-Incorporated Hydroxyapatite Coatings on Titanium Substrates.
Preparation and Characterization of Lanthanum-Incorporated Hydroxyapatite Coatings on Titanium Substrates.
复制标题
钛基体掺镧羟基磷灰石涂层的制备及表征
DOI：
10.3390/ijms160921070
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发表时间：
2015-09-02
影响因子：
5.6
通讯作者：
Wu G
中科院分区：
文献类型：
--
作者：
Lou W;Dong Y;Zhang H;Jin Y;Hu X;Ma J;Liu J;Wu G
钛（Ti）因其优异的生物相容性和力学性能而广泛应用于临床。然而，钛表面的生物惰性促使研究人员通过各种表面修饰（如涂层）来改善植入物的物理化学和生物性能。为此，我们制备了一种新型的生物活性材料，镧-羟基磷灰石（La-HA）涂层，采用La-HA溶胶的浸渍涂层技术以及后热处理。本文的XRD、FTIR和EDX结果证实了镧被成功地掺入到HA的结构中。La-HA涂层由棒状颗粒紧密地压实在一起，无微裂纹。界面剪切强度测试结果表明，镧的加入提高了羟基磷灰石涂层的结合强度。酸性条件下（pH = 5.5）的质量损失率表明La-HA涂层具有较好的耐酸性能。通过碱性磷酸酶的相对活性、细胞形态和体外细胞增殖试验，揭示了La-HA包被的细胞相容性。本研究结果表明，La-HA包被Ti在新型金属植入物生物活性涂层的开发中具有广阔的应用前景。
Titanium (Ti) has been widely used in clinical applications for its excellent biocompatibility and mechanical properties. However, the bioinertness of the surface of Ti has motivated researchers to improve the physicochemical and biological properties of the implants through various surface modifications, such as coatings. For this purpose, we prepared a novel bioactive material, a lanthanum-incorporated hydroxyapatite (La-HA) coating, using a dip-coating technique with a La-HA sol along with post-heat treatment. The XRD, FTIR and EDX results presented in this paper confirmed that lanthanum was successfully incorporated into the structure of HA. The La-HA coating was composed of rod-like particles which densely compacted together without microcracks. The results of the interfacial shear strength test indicated that the incorporation of lanthanum increased the bonding strength of the HA coating. The mass loss ratios under acidic conditions (pH = 5.5) suggested that the La-HA coatings have better acid resistance. The cytocompatibility of the La-HA coating was also revealed by the relative activity of alkaline phosphatase, cellular morphology and cell proliferation assay in vitro. The present study suggested that La-HA coated on Ti has promising potential for applications in the development of a new type of bioactive coating for metal implants.