High-dose thiamine supplementation may reduce resting energy expenditure in individuals with hyperglycemia: a randomized, double – blind cross-over trial
High-dose thiamine supplementation may reduce resting energy expenditure in individuals with hyperglycemia: a randomized, double – blind cross-over trial
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高剂量硫胺素补充剂可能会降低高血糖患者的静息能量消耗：一项随机、双盲交叉试验
DOI：
10.1007/s40200-020-00508-1
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发表时间：
2020
影响因子：
2.8
通讯作者：
J. Sherriff
中科院分区：
文献类型：
--
作者：
F. Alaei;M. Soares;Maryam Lahouti;Yun Zhao;J. Sherriff
背景尽管硫胺素在葡萄糖和能量代谢途径中起着至关重要的作用，但目前还没有发表研究探讨硫胺素对人类能量代谢的影响。目的探讨补充硫胺素对高血糖患者静息能量消耗（REE）的影响。方法12例高血糖患者完成了这项双盲、随机试验，所有参与者均以交叉方式接受硫胺素（300 mg/d）和匹配的安慰剂治疗6周。REE采用间接量热法测定。人体测量，空腹和2小时血糖，和葡萄糖诱导的产热也进行了评估，在开始和完成每个六周的阶段。结果服用硫胺素补充剂的参与者在第六周时与基线[平均值（SE）：1478.93（73.62）vs.1526.40（73.46）kcal/d，p = 0.02]和安慰剂组（p = 0.002）相比，REE显著降低。在调整了参与者的体重和身体活动作为潜在混杂因素后，这些结果没有显著变化。在补充剂组或安慰剂组中，六周的干预对参与者的体重或腰围没有显著影响（所有p值>0.05）。然而，相关性分析突出了在六周的干预期间，REE的变化与空腹（rs = 0.497，p = 0.019）和2小时血糖（rs = 0.498，p = 0.018）的变化之间的显著正相关。结论补充大剂量硫胺素可降低糖调节受损患者的REE水平。我们的研究结果表明，硫胺素对REE的影响可能在一定程度上可以解释为改善血糖控制。试验注册澳大利亚新西兰临床试验注册中心ACTRN 12611000051943。https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx? ACTRN=12611000051943
Background Despite the crucial role of thiamine in glucose and energy metabolism pathways, there has been no published study examining the impact of thiamine on energy metabolism in humans. Objective To assess the effects of thiamine supplementation on resting energy expenditure (REE) in individuals with hyperglycemia. Methods Twelve hyperglycemic patients completed this double-blind, randomized trial, where all participants received both thiamine (300 mg/day) and matched placebo for 6 weeks in a cross-over manner. REE was assessed by indirect calorimetry. Anthropometric measurements, fasting and 2-h plasma glucose, and glucose-induced thermogenesis were also assessed at the beginning and on the completion of each six-week phase. Results Participants consuming thiamine supplements experienced a significant decrease in the REE assessed at week six compared to the baseline [mean (SE): 1478.93 (73.62) vs.1526.40 (73.46) kcal/d, p = 0.02], and the placebo arm ( p = 0.002). These results did not change significantly after adjusting for the participants’ body weight and physical activity as potential confounders. Six-week intervention had no significant effect on the participants’ body weight or waist circumference, in either supplement or placebo arms (all p values>0.05). However, correlation analysis highlighted significant positive relationships between the changes in REE, and those in fasting (r s = 0.497, p = 0.019) and 2-h plasma glucose (r s = 0.498, p = 0.018) during the six-week intervention period. Conclusion Supplementation with high-dose thiamine may attenuate REE in patients with impaired glucose regulation. Our findings suggest that the impact of thiamine on REE may in part be explained by improved glycemic control. Trial registration Australian New Zealand Clinical Trials Registry ACTRN12611000051943. https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12611000051943
影响因子：
7.7
作者：
Itani, SI;Saha, AK;Ruderman, NB
通讯作者：
Ruderman, NB