Polarized expression of p75(NTR) specifies axons during development and adult neurogenesis.
Polarized expression of p75(NTR) specifies axons during development and adult neurogenesis.
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DOI：
10.1016/j.celrep.2014.02.039
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发表时间：
2014-04
期刊：
影响因子：
8.8
通讯作者：
E. Zuccaro;M. Bergami;Beatrice Vignoli;Guillaume Bony;B. Pierchala;S. Santi;L. Cancedda;M. Canossa
中科院分区：
文献类型：
--
作者：
E. Zuccaro;M. Bergami;Beatrice Vignoli;Guillaume Bony;B. Pierchala;S. Santi;L. Cancedda;M. Canossa
新生成的神经元启动指定单个轴突和多个树突的极化信号，这是一个对体内神经元回路模式至关重要的过程。在这里，我们报道了泛神经营养因子受体p75ntri是一种极性调节剂，它在神经营养因子响应的分化神经元中不对称定位，并且是未来轴突规范所必需的。在培养的海马神经元中，局部暴露于神经营养因子会导致p75ntr早期积累到一个未分化的神经突中，从而指定轴突的命运。此外，敲除或敲低p75ntr会导致新生神经元在体外细胞周期结束、发育中的皮层以及体内成体海马神经发生过程中无法启动轴突。因此，p75ntr可以控制神经元极性，决定成人海马和皮质发育中神经元回路的模式和组装。视频摘要
Newly generated neurons initiate polarizing signals that specify a single axon and multiple dendrites, a process critical for patterning neuronal circuits in vivo. Here, we report that the pan-neurotrophin receptor p75NTRis a polarity regulator that localizes asymmetrically in differentiating neurons in response to neurotrophins and is required for specification of the future axon. In cultured hippocampal neurons, local exposure to neurotrophins causes early accumulation of p75NTRinto one undifferentiated neurite to specify axon fate. Moreover, knockout or knockdown of p75NTRresults in failure to initiate an axon in newborn neurons upon cell-cycle exit in vitro and in the developing cortex, as well as during adult hippocampal neurogenesis in vivo. Hence, p75NTRgoverns neuronal polarity, determining pattern and assembly of neuronal circuits in adult hippocampus and cortical development.Video Abstract