Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome
Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome
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DOI：
10.2337/dc05-1801
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发表时间：
2006-06-01
期刊：
影响因子：
16.2
通讯作者：
Kadowaki, Takashi
中科院分区：
文献类型：
--
作者：
Hara, Kazuo;Horikoshi, Momoko;Kadowaki, Takashi
目的 - 据报道，高分子量 (HMW) 形式的脂联素（一种脂肪细胞来源的胰岛素增敏激素）是该激素最活跃的形式。我们使用我们新开发的酶联免疫吸附测定系统选择性测量人类 HMW 脂联素水平，研究了血浆 HMW 脂联素水平的测量是否有助于预测胰岛素抵抗和代谢综合征。 研究设计和方法 - 总共 298 名入院接受糖尿病治疗或冠状动脉造影的患者作为研究对象。绘制 HMW 比率（HMWR；血浆 HMW 脂联素水平与总脂联素水平的比率）和血浆总脂联素水平的受试者工作特征 (ROC) 曲线，以预测胰岛素抵抗和代谢综合征的存在。 结果 - 预测胰岛素抵抗存在的 HMWR 值的 ROC 曲线下面积 (AUC) 显着大于所有受试者的血浆总脂联素水平 (0.713) [95% CI 0.620-0.805] 对比 0.615 [0.522-0.708]，P = 0.0160）。预测是否存在代谢综合征的 HMWR 值的 AUC 显着大于男性（0.806 [0.747-0.865] vs. 0.730 [0.660-0.800]，P = 0.0025）和女性（0.743 [0.659-0.828] vs. 0.637）的血浆总脂联素水平。 [0.532-0.742]，P = 0.0458）。结论 - HMWR 值对胰岛素抵抗和代谢综合征的预测能力优于血浆总脂联素水平。
OBJECTIVE - The high-molecular weight (HMW) form of adiponectin, an adipocyte-derived insulin-sensitizing hormone, has been reported to be the most active form Of this hormone. We investigated whether measurement of plasma HMW adiponectin levels, using our newly developed enzyme-linked immunosorbent assay system for selective measurement of human HMW adiponectin level, may be useful for the prediction of insulin resistance and metabolic syndrome.RESEARCH DESIGN AND METHODS - A total of 298 patients admitted for diabetes treatment or coronary angiography served as study subjects. Receiver operator characteristic (ROC) curves for the HMW ratio (HMWR; ratio of plasma level of HMW adiponectin to that of total adiponectin) and plasma total adiponectin levels were plotted to predict the presence of insulin resistance and metabolic syndrome.RESULTS - The area under the ROC curve (AUC) of the HMWR Values to predict the presence of insulin resistance was significantly larger than that of plasma total adiponectin level in total subjects (0.713 [95% CI 0.620-0.805] vs. 0.615 [0.522-0.708], P = 0.0160). The AUC for the HMWR values to predict the presence of metabolic syndrome was significantly larger than that for plasma total adiponectin levels in men (0.806 [0.747-0.865] vs. 0.730 [0.660-0.800], P = 0.0025) and in women (0.743 [0.659-0.828] vs. 0.637 [0.532-0.742], P = 0.0458).CONCLUSIONS - The HMWR value has better predictive power for the prediction of insulin resistance and metabolic syndrome than plasma total adiponectin level.