4-in-1 phototheranostics: PDA@CoPA-LA nanocomposite for photothermal imaging/photothermal/in-situ O-2 generation/photodynamic combination therapy
4-in-1 phototheranostics: PDA@CoPA-LA nanocomposite for photothermal imaging/photothermal/in-situ O-2 generation/photodynamic combination therapy
复制标题
四合一光治疗：PDA@CoPA-LA 纳米复合材料用于光热成像/光热/原位 O-2 生成/光动力联合治疗
DOI：
10.1016/j.cej.2020.124113
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发表时间：
2020
影响因子：
15.1
通讯作者：
Zhu Manzhou
中科院分区：
文献类型：
--
作者：
Yang Zheng;Liu Xinyu;Wang Xueyan;Wang Pengcheng;Ruan Shanshan;Xie Anjian;Shen Yuhua;Zhu Manzhou
光疗是肿瘤治疗应用中的一个重要分支，具有创伤小、毒性小、使用方便等优点，在肿瘤的临床前和临床治疗中发展迅速。本文合成了一种新型的聚多巴胺（PDA）@植酸钴（CoPA）接枝乳糖酸（LA）的多功能纳米复合材料。以PDA核为模板合成了CoPA，并将其应用于光热成像和光热治疗癌症。CoPA壳层具有良好的双重光响应能力，不仅能诱导单线态氧的形成，还能催化胞内水裂解原位产生O2，增强激光照射下肿瘤细胞的光动力学治疗（PDT）效果。此外，乳糖酸接枝增强了合成纳米复合材料的靶向能力，实现了特异性的靶向肿瘤治疗。体外和体内实验结果均表明，所设计的PDA@CoPA-LA NCs具有良好的协同PTT和PDT效应，并具有特异的靶向性，在临床肿瘤治疗中具有很大的应用潜力。
Phototherapy is an important branch in the application of cancer therapy, having the advantages of low invasion, negligible toxicity, and convenience, which are rapidly developing in the pre-clinic and clinic therapy for cancer. Herein, a novel multifunctional nanocomposite containing polydopamine (PDA)@cobalt phytate (CoPA) with lactose acid (LA) grafting were successfully synthesized. The PDA core was used as the template for the formation of CoPA, and also endowed the obtained nanocomposite with photothermal imaging and photothermal therapy (PTT) to cancers. The CoPA shell possessed excellent dual photo-responsive abilities, not only induced the formation of singlet oxygen, but also catalyzed intracellular water-splitting to produce O2in situ for enhancing photodynamic therapy (PDT) effect on tumor cells under laser irradiation. Furthermore, the lactose acid grafting endued the targeting ability to the synthesized nanocomposites for realizing specific targeted cancer therapy. The experiment resultsin vitroandin vivoboth demonstrate that the designed PDA@CoPA-LA NCs have excellent synergistic PTT and PDT effect enhanced by in situ O2-generation with specific targeted performance, exhibiting great potential in the application for clinic cancer therapy.