MICRONUTRIENTS AND HIV-1 DISEASE PROGRESSION
MICRONUTRIENTS AND HIV-1 DISEASE PROGRESSION
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DOI：
10.1097/00002030-199509000-00010
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发表时间：
1995-09-01
期刊：
影响因子：
3.8
通讯作者：
HENNEKENS, CH
中科院分区：
文献类型：
--
作者：
BAUM, MK;SHORPOSNER, G;HENNEKENS, CH
目的：确定营养状况是否影响免疫学标记设计：一项纵向研究，在18个月的随访中评估血浆营养水平和CD 4细胞计数之间的关系，沿着和与β 2微球蛋白（β 2 M; AIDS指数）结合。方法：营养状态的生化测量，包括血浆蛋白、锌、铁和维生素B-1、B-2、B-6、B-12在108名HIV-1血清阳性的同性恋男性中，在基线和三个6个月的时间段内获得了维生素A、维生素E、维生素C和叶酸以及免疫学标记物[淋巴细胞亚群（CD 4）和β（2）M]。营养状况的变化（例如，正常到缺陷，缺陷到正常），与免疫学参数在相同的时间段内使用自回归模型进行比较。维生素A或维生素B-12缺乏的发展与CD 4细胞计数下降有关（P分别为0.0255和0.0377），而维生素A、维生素B-12和锌的正常化与较高的CD 4细胞计数相关（P值分别为0.0492、0.0061和0.0112）。这些发现基本上不受齐多夫定使用的影响。对于维生素B-12低基线状态显着预测加速HIV-1疾病的进展确定的CD 4细胞计数（P=0.041）和艾滋病指数（P=0.005）。结论：这些数据表明，微量营养素缺乏与HIV-1疾病的进展，并提高正常化可能会增加无瘤生存的可能性。
Objective: To determine whether nutritional status affects immunological markeDesign: A longitudinal study, to evaluate the relationship between plasma levels of nutrients and CD4 cell counts, along and in combination with beta(2)-microglobulin (beta(2)M; AIDS index) over an 18-month follow-up.Methods: Bicohemical measurements of nutritional status including plasma proteins, zinc, iron and vitamins B-1, B-2, B-6, B-12 (cobalamin), A, E, C and folate and immunological markers [lymphocyte subpopulations (CD4) and beta(2)M] were obtained in 108 HIV-1-seropositive homosexual men at baseline and over three 6-month time periods. Changes in nutrient status (e.g., normal to deficient, deficient to normal), were compared with immunological parameters in the same time periods using an autoregressive model.Results: Development of deficiency of vitamin A or vitamin B-12 was associated with a decline in CD4 cell count (P=0.0255 and 0.0377, respectively), while normalization of vitamin A, vitamin B-12 and zinc was associated with higher CD4 cell counts (P=0.0492, 0.0061 and 0.0112, respectively). These findings were largely unaffected by zidovudine use. For vitamin B-12 low baseline status significantly predicted accelerated HIV-1 disease progression determined by CD4 cell count (P=0.041) and the AIDS index (P=0.005).Conclusions: These data suggest that micronutrient deficiencies are associated with HIV-1 disease progression and raise the possibility that normalization might increase symptom-free survival.