EFFECT OF INJECTABLE OR INHALATIONAL ANESTHETICS AND OF NEUROLEPTIC, NEUROLEPTANALGESIC, AND SEDATIVE AGENTS ON TUMOR BLOOD-FLOW
EFFECT OF INJECTABLE OR INHALATIONAL ANESTHETICS AND OF NEUROLEPTIC, NEUROLEPTANALGESIC, AND SEDATIVE AGENTS ON TUMOR BLOOD-FLOW
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DOI：
10.2307/3577144
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发表时间：
1988-04-01
影响因子：
3.4
通讯作者：
VAUPEL, P
中科院分区：
文献类型：
--
作者：
MENKE, H;VAUPEL, P
在其他参数中，不同的血流量值可能是实验性啮齿动物肿瘤的放射生物学缺氧细胞部分在肿瘤间变化的原因。为了检验放射生物学中常用的麻醉药是否会引起肿瘤血流的改变，我们采用85Kr清除技术研究了注射麻醉药和吸入麻醉药以及抗精神病药、抗精神病药和镇静剂对sd - dawley大鼠皮下ds -癌肉瘤血流的影响。在有意识的大鼠中，动物测量后20-100分钟平均血流量为0.62±。0.17 ml/g/ml (.hivin。x。+ -。SD)在0.75。0.15 g肿瘤，平均动脉血压125±。在接受硫代丁巴比妥、水合氯醛或甲氧基氟醚治疗的动物中，肿瘤血流量略高于清醒大鼠。接受依托咪酯、氯胺酮-噻嗪、芬太尼-氟尼松或氨基甲酸乙酯治疗的动物的肿瘤血流量明显低于硫代丁巴比妥组，并略低于清醒的动物。使用咪达唑仑、氯胺酮咪达唑仑、芬太尼-氟哌啶醇、氟哌啶醇、地西泮和戊巴比妥观察到的血流值与清醒大鼠相似。在意识清醒的大鼠和大多数使用的药物中，几乎没有检测到血流随时间的变化。在用聚氨酯或甲氧基氟醚麻醉的动物中，随着时间的推移，肿瘤血流量增加，肿瘤血管阻力略有下降。
Among other parameters, varying blood flow values may be responsible for tumor-to-tumor variabilities in the radiobiologically hypoxic cell fraction of experimental rodent tumors. To test whether changes in tumor blood flow may be caused by anesthetic agents often used in radiobiology, the effect of injectable and inhalational anesthetics and of neuroleptic, neurolept-analgesic, and sedative agents on blood flow in subcutaneous DS-carcinosarcoma implanted in Sprague-Dawley rats has been investigated using the 85Kr clearance technique. In conscious rats, 20-100 min after animal instrumentation mean blood flow is 0.62 .+-. 0.17 ml/g/ml (.hivin.x .+-. SD) in 0.75 .+-. 0.15 g tumors at a mean arterial blood pressure of 125 .+-. 12 mm Hg. In animals receiving thiobutabarbital, chloral hydrate, or methoxyflurane tumor blood flow is somewhat higher than that measured in conscious rats. Tumor blood flow in animals receiving etomidate, ketamine-xylazine, fentanyl-fluanisone, or urethane is significantly lower than that in the thiobutabarbital group and somewhat lower than in the conscious animals. Blood flow values observed with midazolam, ketamine-midazolam, fentanyl-droperidol, droperidol, diazepam, and pentobarbital are similar to those measured in conscious rats. Virtually no flow alterations with time are detectable in conscious rats and with most of the drugs used. In animals anesthetized with urethane or methoxyflurane, tumor blood flow increases and tumor vascular resistance diminishes slightly with time.