Central indomethacin enhances volume-dependent vasopressin release.
Central indomethacin enhances volume-dependent vasopressin release.
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中枢吲哚美辛增强体积依赖性加压素释放。
DOI：
10.1152/ajpregu.1984.247.6.r1017
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Nasjletti,A
中科院分区：
文献类型：
--
作者：
Brooks,DP;Share,L;Crofton,JT;Nasjletti,A
在吗啡镇静、乌拉坦/氯醛糖麻醉的狗中研究了集中给予吲哚美辛对出血引起的加压素释放的影响。脑室池灌注吲哚美辛 1) 显着降低小脑延髓池流出物中前列腺素 E2 的含量，2) 显着增强加压素对容量不足的反应，并导致严重出血期间平均动脉血压大幅下降。结果表明，中枢前列腺素可能对容量不足期间的加压素分泌具有抑制作用。
The effect of centrally administered indomethacin on hemorrhage-induced vasopressin release was studied in the morphine-sedated, urethan/chloralose-anesthetized dog. Ventriculocisternal perfusion of indomethacin 1) significantly reduced the amount of prostaglandin E2 in the effluent from the cisterna magna, 2) significantly enhanced the vasopressin response to volume depletion, and led to a greater fall in mean arterial blood pressure during severe hemorrhage. The results suggest that central prostaglandins may have an inhibitory effect on vasopressin secretion during volume depletion.