Behavioral effects of psychomotor stimulant infusions into amygdaloid nuclei
Behavioral effects of psychomotor stimulant infusions into amygdaloid nuclei
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DOI：
10.1016/s0893-133x(98)00083-9
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发表时间：
1999-06-01
影响因子：
7.6
通讯作者：
Neisewander, JL
中科院分区：
文献类型：
--
作者：
O'Dell, LE;Sussman, AN;Neisewander, JL
研究了杏仁核在精神运动兴奋剂引起的运动、刻板印象和条件位置偏好（CPP）中的作用。连续10天进行5次2天条件反射试验。将生理盐水、可卡因（25-100 μ g/侧）或安非他明（0.31-20 μ g/侧）分别注入大鼠脑室（ICV）、杏仁核基底外侧（BlA）或杏仁核中央（CeA），并将其限制在一个隔间内。在隔天，大鼠接受假输注，并被限制在不同的隔室。每天测量运动，试验1和试验5测量刻板印象，并在条件反射后24 h测量CPP。静脉注射可卡因或安非他明产生运动、饲养和CPP。在bla和cea内注射最高剂量的可卡因产生运动。相反，cea内注射安非他明能产生运动和CPP。然而，在bla内注射安非他明并没有产生任何行为改变。这些结果表明，CeA，而不是BlA，参与了安非他明产生的奖赏和运动的启动。(C) 1999美国神经精神药理学学会。Elsevier Science Inc.出版。
The role of amygdaloid nuclei in locomotion, stereotypy, and conditioned place preference (CPP) produced by psychomotor stimulants was examined. Five 2-day conditioning trials were conducted over 10 consecutive days. Rats received bilateral intracranial infusions of saline, cocaine (25-100 mu g/side), or amphetamine (0.31-20 mu g/side) into the ventricles (ICV), basolateral amygdala (BlA), or central amygdala (CeA) and were confined to a compartment. On alternating days, rats received sham infusions and were confined to a different compartment. Locomotion was measured daily, stereotypy was measured on trials 1 and 5, and CPP was measured 24 h after conditioning. ICV infusions of cocaine or amphetamine produced locomotion, rearing, and CPP. Intra-BlA and intra-CeA infusions of the highest dose of cocaine produced locomotion. In contrast, intra-CeA infusions of amphetamine potently produced locomotion and CPP. Intra-BlA infusions of amphetamine, however, did not produce any behavioral changes. These results suggest that the CeA, but not the BlA, is involved in initiating reward and locomotion produced by amphetamine. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.