Changes in electroencephalographic activities following pressure stimulation in humans
Changes in electroencephalographic activities following pressure stimulation in humans
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DOI：
10.1111/j.1440-1819.2005.01431.x
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发表时间：
2005-12-01
影响因子：
11.9
通讯作者：
Yamasaki, Y
中科院分区：
文献类型：
--
作者：
Ishitani, N;Masumoto, Y;Yamasaki, Y
我们研究了20名健康受试者对口面部疼痛反应的大脑活动，以表征疼痛与脑功能变化之间的关系。首先，用压力计测量20例受试者在颞骨茎突(Libman‘s点)的压痛阈值(PPT)。其次，测量了20名受试者在10 S恒压刺激利氏穴位前后的脑电变化。将20例受试者分为两组：高PPT组(10例)和低PPT组(10例)。低刺激组刺激后脑电β活动的变化大于高刺激组，并且这种变化与PPT呈显著负相关，即使是微小的持续刺激也会引起高疼痛接受者更大的脑电变化。目前的研究表明，在疼痛刺激后，PPT较低的受试者比PPT较高的受试者β活动的相对减少更为显著，这种变化与大脑半球的平衡密切相关，即使是微小的持续刺激也会引起对疼痛高度敏感的个体脑波的变化。
We investigated brain activity in response to orofacial pain in 20 healthy subjects in order to characterize the relationship between pain and changes in brain function. First, the pressure pain threshold (PPT) at the styloid process of the temporal bone (Libman's point) of 20 subjects was measured by a pressure algometer. Second, electroencephalographic (EEG) changes of 20 subjects before and after 10 s of constant pressure stimulation at Libman's point were measured. These 20 subjects were divided into two groups: 10 subjects with higher PPT (high group) and 10 subjects with lower PPT (low group). EEG change in beta activity after stimulation was greater in the low group than the high group, and there was a significant negative correlation between this change and PPT, with even minor constant stimulation inducing larger EEG change in individuals highly receptive to pain. The present study demonstrated that a relative reduction in beta activity after pain stimulation was more remarkable in subjects with lower PPT than in subjects with higher PPT, and that this change was closely related to a hemispheric balance, with even minor constant stimulation inducing changes in brain waves in individuals highly sensitive to pain.