Effects of intermittent parathyroid hormone treatment on new bone formation during distraction osteogenesis in the rat mandible
Effects of intermittent parathyroid hormone treatment on new bone formation during distraction osteogenesis in the rat mandible
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DOI：
10.1016/j.oooo.2011.08.009
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发表时间：
2012-07-01
影响因子：
2.9
通讯作者：
Saito, Chikara
中科院分区：
文献类型：
--
作者：
Ali, Mir Nowazesh;Kobayashi, Tadaharu;Saito, Chikara
目标。采用微计算机断层扫描技术评估间歇性甲状旁腺激素（PTH[1-34]）治疗对下颌骨牵张大鼠骨再生的影响。研究设计。潜伏期5 d后，18只大鼠以0.2 mm/12小时的速度分散下颌骨，连续10天，甲状旁腺激素组和对照组大鼠分别以60 μ g/kg体重皮下注射甲状旁腺激素（1-34）或只注射一辆车，每周3次。分别于疏导10 d、整理1周、整理3周后人道处死。在重建的下颌骨分散的三维图像中，PTH组在所有时间点的期望感兴趣区域的平均骨体积均显著大于对照组。在大鼠下颌牵张模型中，间歇性PTH（1-34）治疗可促进新骨形成，并可能有效缩短巩固期。（口腔外科口腔医学口腔病理口腔放射学2012；114:e36-e42）
Objective. The effect of intermittent parathyroid hormone (PTH[1-34]) treatment on bone regeneration in a rat model of mandibular distraction was evaluated using microcomputed tomography.Study Design. After a 5-day latency period, mandibles of 18 rats were distracted at 0.2 mm/12 hours for 10 days, and rats in the PTH and control groups received subcutaneous injections of PTH(1-34) at a dosage of 60 mu g/kg body weight or a vehicle only, respectively, 3 times a week. The animals were humanely killed after 10 days of distraction and after 1 week and 3 weeks of consolidation.Results. In reconstructed 3-dimensional images of the distracted mandible, mean bone volumes of the desired region of interest in the PTH group were significantly larger than those in the control group at all time points.Conclusions. Intermittent PTH(1-34) treatment enhances new bone formation during mandibular distraction in a rat model, and it may be effective for shortening the consolidation period. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:e36-e42)