Resolution below the point spread function for diffuse optical imaging using fluorescence lifetime multiplexing.
Resolution below the point spread function for diffuse optical imaging using fluorescence lifetime multiplexing.
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DOI：
10.1364/ol.38.002038
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发表时间：
2013-06-15
期刊：
影响因子：
3.6
通讯作者：
Kumar AT
中科院分区：
文献类型：
--
作者：
Rice WL;Hou S;Kumar AT
我们表明，渐近寿命为基础的荧光断层扫描可以本地化多寿命的目标分离以及以下的混浊介质的扩散点扩散函数。这是可能的，由于一个完整的对角化的时域正问题的渐近极限。我们还表明，连续波或直接的时间门方法荧光断层扫描是无法实现这种分离，表明一个独特的优势，基于衰减幅度的方法断层成像寿命复用与时域数据。
We show that asymptotic lifetime-based fluorescence tomography can localize multiple-lifetime targets separated well below the diffuse point spread function of a turbid medium. This is made possible due to a complete diagonalization of the time domain forward problem in the asymptotic limit. We also show that continuous wave or direct time gate approaches to fluorescence tomography are unable to achieve this separation, indicating the unique advantage of a decay-amplitude-based approach for tomographic lifetime multiplexing with time domain data.