Coordinate expression of cyclooxygenase-2 and renin in the rat kidney in renovascular hypertension
Coordinate expression of cyclooxygenase-2 and renin in the rat kidney in renovascular hypertension
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DOI：
10.1161/01.hyp.31.1.201
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发表时间：
1998-01-01
期刊：
影响因子：
8.3
通讯作者：
Hilgers, KF
中科院分区：
文献类型：
--
作者：
Hartner, A;Goppelt-Struebe, M;Hilgers, KF
前列腺素有助于调节肾素的合成和分泌。我们验证了前列腺素G/H合成酶的诱导异构体环氧化酶-2在肾血管性高血压中促进肾素合成的假设。研究了双肾、单夹肾血管性高血压和假手术大鼠肾脏中环氧化酶-2和肾素的表达。剪接后2周收缩压升高(153+/-7，对照组112+/-4 mmHg， n=6， P
Prostaglandins contribute to the regulation of renin synthesis and secretion. We tested the hypothesis that the inducible isoform of prostaglandin G/H synthase, cyclooxygenase-2, contributes to the stimulation of renin synthesis in renovascular hypertension. The expression of cyclooxygenase-2 and renin was investigated in the kidneys of rats with two-kidney, one-clip renovascular hypertension or sham operation. Systolic blood pressure was increased 2 weeks after clipping (153+/-7 versus 112+/-4 mmHg in controls, n=6 each, P