Histo-Blood Group Antigen Phenotype Determines Susceptibility to Genotype-Specific Rotavirus Infections and Impacts Measures of Rotavirus Vaccine Efficacy.
Histo-Blood Group Antigen Phenotype Determines Susceptibility to Genotype-Specific Rotavirus Infections and Impacts Measures of Rotavirus Vaccine Efficacy.
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DOI：
10.1093/infdis/jiy054
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发表时间：
2018-04-11
期刊：
影响因子：
--
通讯作者：
Kirkpatrick BD
中科院分区：
文献类型：
--
作者：
Lee B;Dickson DM;deCamp AC;Ross Colgate E;Diehl SA;Uddin MI;Sharmin S;Islam S;Bhuiyan TR;Alam M;Nayak U;Mychaleckyj JC;Taniuchi M;Petri WA Jr;Haque R;Qadri F;Kirkpatrick BD
Lewis and secretor histo–blood group antigens (HBGAs) have been associated with decreased susceptibility to P[8] genotype rotavirus (RV) infections. Efficacy of vaccines containing attenuated P[8] strains is decreased in low-income countries. Host phenotype might impact vaccine efficacy (VE) by altering susceptibility to vaccination or RV diarrhea (RVD). We performed a substudy in a monovalent RV vaccine (RV1) efficacy trial in Bangladesh to determine the impact of Lewis and secretor status on risk of RVD and VE. In infants randomized to receive RV1 or no RV1 at 10 and 17 weeks with 1 year of complete active diarrheal surveillance, we performed Lewis and secretor phenotyping and genotyped the infecting strain of each episode of RVD. A vaccine containing P[8] RV protected secretors and nonsecretors similarly. However, unvaccinated nonsecretors had a reduced risk of RVD (relative risk, 0.53 [95% confidence interval, .36–.79]) mediated by complete protection from P[4] but not P[8] RVs. This effect reduced VE in nonsecretors to 31.7%, compared to 56.2% among secretors, and decreased VE for the overall cohort. Host HBGA status may impact VE estimates by altering susceptibility to RV in unvaccinated children; future trials should therefore account for HBGA status. NCT01375647. Histo–blood group antigens were associated with genotype-specific susceptibility to rotavirus infections. Nonsecretors were at decreased risk of P[4] infections, while Lewis-negative children were at increased risk of P[6] infections. These effects may impact oral rotavirus vaccine efficacy estimates.
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影响因子：
11.1
作者：
Naylor C;Lu M;Haque R;Mondal D;Buonomo E;Nayak U;Mychaleckyj JC;Kirkpatrick B;Colgate R;Carmolli M;Dickson D;van der Klis F;Weldon W;Steven Oberste M;PROVIDE study teams;Ma JZ;Petri WA Jr
通讯作者：
Petri WA Jr
影响因子：
9.4
作者：
Verkerke H;Sobuz S;Ma JZ;Petri SE;Reichman D;Qadri F;Rahman M;Haque R;Petri WA Jr
通讯作者：
Petri WA Jr
影响因子：
6.4
作者：
Kazi, Abdul Momin;Cortese, Margaret M.;Ali, Asad
通讯作者：
Ali, Asad
影响因子：
11.8
作者：
Ayouni S;Sdiri-Loulizi K;de Rougemont A;Estienney M;Ambert-Balay K;Aho S;Hamami S;Aouni M;Neji-Guediche M;Pothier P;Belliot G
通讯作者：
Belliot G
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y