Photosensitivity due to a fluorouracil derivative.
Photosensitivity due to a fluorouracil derivative.
复制标题
氟尿嘧啶衍生物引起的光敏性。
DOI：
10.1001/archderm.1978.01640220047012
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发表时间：
1978
影响因子：
--
通讯作者：
K. Ikai
中科院分区：
文献类型：
--
作者：
T. Horio;T. Murai;K. Ikai
1例63岁男性患者术后接受1-(2-四氢呋喃)-5-氟尿嘧啶化疗时出现光敏性扁平苔藓样疹。光敏性的作用光谱在长波紫外光(UV-A)。在给药和暴露于UV-A的情况下，反应是可重复性的。在这次测试时，在以前涉及的地点观察到了耀斑现象。这种药物的感光试验呈阴性。服用该药的患者没有皮炎，对UV-A不敏感。这些观察表明，患者体内发生的光敏反应可能是光敏反应。
A photosensitive lichen planus-like eruption developed in a 63-year-old man during postoperative chemotherapy with 1-(2-tetrahydrofuryl)-5-fluorouracil. The action spectrum for the photosensitivity was in the long-wave ultraviolet light (UV-A). The reaction was reproducible on readministration of the drug and exposure to UV-A. At the time of this test, a flare-up phenomenon was observed at previously involved sites. The photopatch test was negative with the drug. Patients taking the drug who had no dermatitis were not sensitive to UV-A. These observations suggest that the photosensitivity that occurred in the patient was possibly photoallergic.