Interim results of an ecological experiment - Conjugate vaccination against the pneumococcus and serotype replacement.
Interim results of an ecological experiment - Conjugate vaccination against the pneumococcus and serotype replacement.
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DOI：
10.1080/21645515.2015.1118593
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发表时间：
2016
影响因子：
4.8
通讯作者：
Hanage WP
中科院分区：
文献类型：
--
作者：
Hausdorff WP;Hanage WP
肺炎链球菌有超过95种血清型，每种血清型都可能导致败血症、脑膜炎、肺炎和急性中耳炎。尽管如此，针对有限数量血清型的肺炎球菌结合疫苗（PCV）对肺炎球菌疾病的每种表现都有显著影响。与此同时，越来越多的证据表明，在实施婴儿PCV计划后发生了重大的非疫苗型（NVT）替代疾病，这引发了对PCV免疫策略的长期可行性以及如何优化PCV制剂的问题。我们在这里讨论了关于血清型替代的理论和实践考虑，并提供了在实施2种高价PCV后迄今为止看到的最重要的NVT类型的快照。
Streptococcus pneumoniae has more than 95 serotypes, each of which presumably can cause sepsis, meningitis, pneumonia, and acute otitis media. Pneumococcal conjugate vaccines (PCV) targeted against a limited number of serotypes have nonetheless revealed an impressive impact on each manifestation of pneumococcal disease. At the same time, growing evidence of significant non-vaccine type (NVT) replacement disease following implementation of infant PCV programs has raised questions about the long-term viability of PCV immunization strategies and how to optimize PCV formulations. We discuss here theoretical and practical considerations regarding serotype replacement, and provide a snapshot of the most important NVT types seen to date after implementation of the 2 higher-valent PCVs.
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影响因子：
3.6
作者：
Black, S;Shinefield, H;Edwards, K
通讯作者：
Edwards, K
影响因子：
15.8
作者：
Feikin, Daniel R.;Kagucia, Eunice W.;Moore, Matthew R.
通讯作者：
Moore, Matthew R.
影响因子：
24.3
作者：
Burgos, Joaquin;Lujan, Manel;Pahissa, Albert
通讯作者：
Pahissa, Albert
影响因子：
158.5
作者：
Eskola, J;Kilpi, T;Ecrola, M
通讯作者：
Ecrola, M
影响因子：
5.5
作者：
Bruce, Michael G.;Singleton, Rosalyn;Hennessy, Thomas
通讯作者：
Hennessy, Thomas