Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study
Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study
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DOI：
10.18632/aging.103372
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发表时间：
2020-06-30
期刊：
影响因子：
5.2
通讯作者：
Gu, Guorong
中科院分区：
文献类型：
--
作者：
Han, Yi;Zhang, Haidong;Gu, Guorong
背景：世界卫生组织已宣布 2019 年冠状病毒病（COVID-19）为全球关注的突发公共卫生事件。对病例的更新分析可能有助于确定疾病严重程度的危险因素。结果：中位年龄为 63 岁，44.9% 为重症病例。重症患者入院时APACHE II（8.5 vs. 4.0）和SOFA（2 vs. 1）评分较高。在所有单变量参数中，淋巴细胞、CRP 和 LDH 是 COVID-19 严重程度的显着独立危险因素。 LDH与APACHE II和SOFA评分以及P/F比和CT评分呈正相关。 LDH (AUC = 0.878) 也具有最大特异性 (96.9%)，截止值为 344.5。此外，LDH与CRP、AST、BNP、cTnI呈正相关，与淋巴细胞及其亚群呈负相关。结论：本研究表明，LDH 可以被认为是早期识别肺损伤和重症 COVID-19 病例的有力预测因素。 方法：我们提取了武汉大学人民医院 107 例确诊的 COVID-19 患者的数据。根据美国胸科学会社区获得性肺炎指南，在入院时定义了 COVID-19 患者的严重程度（严重与非严重）。
Background: The World Health Organization has declared coronavirus disease 2019 (COVID-19) a public health emergency of global concern. Updated analysis of cases might help identify the risk factors of illness severity.Results: The median age was 63 years, and 44.9% were severe cases. Severe patients had higher APACHE II (8.5 vs. 4.0) and SOFA (2 vs. 1) scores on admission. Among all univariable parameters, lymphocytes, CRP, and LDH were significantly independent risk factors of COVID-19 severity. LDH was positively related both with APACHE II and SOFA scores, as well as P/F ratio and CT scores. LDH (AUC = 0.878) also had a maximum specificity (96.9%), with the cutoff value of 344.5. In addition, LDH was positively correlated with CRP, AST, BNP and cTnI, while negatively correlated with lymphocytes and its subsets. Conclusions: This study showed that LDH could be identified as a powerful predictive factor for early recognition of lung injury and severe COVID-19 cases.Methods: We extracted data regarding 107 patients with confirmed COVID-19 from Renmin Hospital of Wuhan University. The degree of severity of COVID-19 patients (severe vs. non-severe) was defined at the time of admission according to American Thoracic Society guidelines for community acquired pneumonia.