Indirect regulation of PCSK9 gene in inflammatory response by Porphyromonas gingivalis infection.
Indirect regulation of PCSK9 gene in inflammatory response by Porphyromonas gingivalis infection.
复制标题
PCSK9基因在牙龈卟啉单胞菌感染炎症反应中的间接调节。
DOI：
10.1016/j.heliyon.2018.e01111
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发表时间：
2019
期刊：
影响因子：
4
通讯作者：
Yamazaki K.
中科院分区：
文献类型：
--
作者：
Yokoji-Takeuchi M;Tabeta K;Takahashi N;Arimatsu K;Miyazawa H;Matsuda-Matsukawa Y;Sato K;Yamada M;Yamazaki K.
Pro-protein convertase subtilisin/kexin type 9 (PCSK9), a secreted serine protease, regulates serum low-density lipoprotein (LDL) cholesterol levels by targeting the degradation of LDL receptor (LDLR) in the liver. Although previous reports describe elevated levels of PCSK9 in patients with periodontitis, the mechanisms that trigger this increase in serum PCSK9 levels and induce the related inflammatory response remain unclear. In an unc93b1-deficient mouse of Porphyromonas gingivalis infection, nucleic acid antigen recognition via Tolllike receptors was found to promote PCSK9 production, suggesting an indirect role for tumor necrosis factor-α as an inducer of PCSK9 in contrast to that reported in previous studies. Furthermore, PCSK9 production was independent of the TIR domain-containing adapter-inducing interferon-β-dependent signaling pathway. These results indicate that changes in LDLR expression precede an increase in the serum PCSK9 level in the context of an infectious disease such as periodontitis.学位の種類: 博士 (歯学). 報告番号: 甲第 4575 号. 学位記番号: 新大院博 (歯) 甲第 424 号. 学位授与年月日: 平成 31 年 3 月 25 日