Developmental specification of metabolic circuitry.
Developmental specification of metabolic circuitry.
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DOI：
10.1016/j.yfrne.2015.09.003
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发表时间：
2015-10
影响因子：
7.4
通讯作者：
Simerly RB
中科院分区：
文献类型：
--
作者：
Elson AE;Simerly RB
下丘脑包含一个与脑干和脊髓沟通的核心回路，以调节能量平衡。由于代谢表型在围产期发育过程中受到环境变量的影响，因此重要的是要了解这些神经通路如何形成，以确定负责代谢编程的关键信号通路。最近的进展，在定义基因表达事件，指导下丘脑的早期模式和细胞规格，以及在我们的理解中枢神经内分泌通路的激素控制的进展，建议几个关键的监管节点，可能代表目标的代谢编程的大脑结构和功能。这篇评论的重点是已知的中央电路的组成部分，以调节能量平衡的各个方面，并总结了什么是已知的代谢编程的背景下，他们的发育神经生物学。
The hypothalamus contains a core circuitry that communicates with the brainstem and spinal cord to regulate energy balance. Because metabolic phenotype is influenced by environmental variables during perinatal development, it is important to understand how these neural pathways form in order to identify key signaling pathways that are responsible for metabolic programming. Recent progress in defining gene expression events that direct early patterning and cellular specification of the hypothalamus, as well as advances in our understanding of hormonal control of central neuroendocrine pathways, suggest several key regulatory nodes that may represent targets for metabolic programming of brain structure and function. This review focuses on components of central circuitry known to regulate various aspects of energy balance and summarizes what is known about their developmental neurobiology within the context of metabolic programming.