Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants
Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants
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DOI：
10.1056/nejmoa2030391
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发表时间：
2021-01-07
影响因子：
158.5
通讯作者：
Ogawa, Chitose
中科院分区：
文献类型：
--
作者：
Arakawa, Ayumu;Ichikawa, Hitoshi;Ogawa, Chitose
在对肿瘤和正常组织配对样本进行常规下一代测序期间，偶然检测到两例由宫颈肿瘤母婴传播引起的儿童肺癌（23个月大和6岁男孩）。第一个孩子的一些病变的自发消退和第二个孩子的肿瘤块的缓慢生长表明存在针对所传播的肿瘤的同种免疫反应。使用nivolumab的免疫检查点抑制剂治疗导致第一个孩子中所有剩余肿瘤的强烈消退。
Two cases of pediatric lung cancer (in 23-month-old and 6-year-old boys) resulting from mother-to-infant transmission of uterine cervical tumors were incidentally detected during routine next-generation sequencing of paired samples of tumor and normal tissue. Spontaneous regression of some lesions in the first child and slow growth of the tumor mass in the second child suggested the existence of alloimmune responses against the transmitted tumors. Immune checkpoint inhibitor therapy with nivolumab led to a strong regression of all remaining tumors in the first child.